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Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: The effect of krill oil supplementation on skeletal muscle function and size in older adults: A randomised controlled trial
Author(s): Alkhedhairi, Saleh A A
Aba Alkhayl, Faris F
Ismail, Ahmad D
Rozendaal, A
German, M
MacLean, Beth
Johnston, Lynsey
Miller, Alyson A
Hunter, Angus M
Macgregor, Lewis J
Combet, Emilie
Quinn, Terrence J
Gray, Stuart R
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Keywords: Sarcopenia
Issue Date: Jun-2022
Date Deposited: 31-May-2022
Citation: Alkhedhairi SAA, Aba Alkhayl FF, Ismail AD, Rozendaal A, German M, MacLean B, Johnston L, Miller AA, Hunter AM, Macgregor LJ, Combet E, Quinn TJ & Gray SR (2022) The effect of krill oil supplementation on skeletal muscle function and size in older adults: A randomised controlled trial. Clinical Nutrition, 41 (6), pp. 1228-1235.
Abstract: Background & aims The aim of this study was to determine the effect of krill oil supplementation, on muscle function and size in healthy older adults. Methods Men and women, aged above 65 years, with a BMI less than 35kg/m2, who participated in less than 1h per week of structured self-reported exercise, were enrolled in the study (NCT04048096) between March 2018 and March 2020. Participants were randomised to either control or krill oil supplements (4g/day) for 6 months in this double blind randomised controlled trial. At baseline, 6 weeks and 6 months, knee extensor maximal torque was measured as the primary outcome of the study. Secondary outcomes measured were grip strength, vastus lateralis muscle thickness, short performance physical battery test, body fat, muscle mass, blood lipids, glucose, insulin, and C-Reactive Protein, neuromuscular (M-Wave, RMS and voluntary activation), and erythrocyte fatty acid composition. Results A total of 102 men and women were enrolled in the study. Ninety-four participants (krill group (26 women and 23 men) and placebo group (27 women and 18 men)) completed the study (mean (SD): age 71.2 (5.1) years and weight 71.8 (12.3) kg). Six months supplementation with krill oil resulted in, an increase in knee extensor maximal torque, grip strength and vastus lateralis muscle thickness, relative to control (p
DOI Link: 10.1016/j.clnu.2022.04.007
Rights: This is an open access article distributed under the terms of the Creative Commons CC-BY license (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You are not required to obtain permission to reuse this article.
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