Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/34251
Full metadata record
DC FieldValueLanguage
dc.contributor.authorVelázquez-Wallraf, Aliciaen_UK
dc.contributor.authorFernández, Antonioen_UK
dc.contributor.authorCaballero, Maria Joseen_UK
dc.contributor.authorArregui, Marinaen_UK
dc.contributor.authorGonzález Díaz, Óscaren_UK
dc.contributor.authorBetancor, Monica Ben_UK
dc.contributor.authorBernaldo de Quirós, Yaraen_UK
dc.date.accessioned2022-05-04T00:06:35Z-
dc.date.available2022-05-04T00:06:35Z-
dc.date.issued2022en_UK
dc.identifier.other6592en_UK
dc.identifier.urihttp://hdl.handle.net/1893/34251-
dc.description.abstractDecompression sickness (DCS) is a clinical syndrome caused by the formation of systemic intravascular and extravascular gas bubbles. The presence of these bubbles in blood vessels is known as gas embolism. DCS has been described in humans and animals such as sea turtles and cetaceans. To delve deeper into DCS, experimental models in terrestrial mammals subjected to compression/decompression in a hyperbaric chamber have been used. Fish can suffer from gas bubble disease (GBD), characterized by the formation of intravascular and extravascular systemic gas bubbles, similarly to that observed in DCS. Given these similarities and the fact that fish develop this disease naturally in supersaturated water, they could be used as an alternative experimental model for the study of the pathophysiological aspect of gas bubbles. The objective of this study was to obtain a reproducible model for GBD in fish by an engineering system and a complete pathological study, validating this model for the study of the physiopathology of gas related lesions in DCS. A massive and severe GBD was achieved by exposing the fish for 18 h to TDG values of 162–163%, characterized by the presence of severe hemorrhages and the visualization of massive quantities of macroscopic and microscopic gas bubbles, systemically distributed, circulating through different large vessels of experimental fish. These pathological findings were the same as those described in small mammals for the study of explosive DCS by hyperbaric chamber, validating the translational usefulness of this first fish model to study the gas-bubbles lesions associated to DCS from a pathological standpoint.en_UK
dc.language.isoenen_UK
dc.publisherNature Publishing Groupen_UK
dc.relationVelázquez-Wallraf A, Fernández A, Caballero MJ, Arregui M, González Díaz Ó, Betancor MB & Bernaldo de Quirós Y (2022) Establishment of a fish model to study gas-bubble lesions. Scientific Reports, 12, Art. No.: 6592. https://doi.org/10.1038/s41598-022-10539-8en_UK
dc.rightsThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.titleEstablishment of a fish model to study gas-bubble lesionsen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1038/s41598-022-10539-8en_UK
dc.identifier.pmid35449183en_UK
dc.citation.jtitleScientific Reportsen_UK
dc.citation.issn2045-2322en_UK
dc.citation.volume12en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.citation.date21/04/2022en_UK
dc.contributor.affiliationUniversidad de Las Palmas de Gran Canariaen_UK
dc.contributor.affiliationUniversidad de Las Palmas de Gran Canariaen_UK
dc.contributor.affiliationUniversidad de Las Palmas de Gran Canariaen_UK
dc.contributor.affiliationUniversidad de Las Palmas de Gran Canariaen_UK
dc.contributor.affiliationUniversidad de Las Palmas de Gran Canariaen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationUniversidad de Las Palmas de Gran Canariaen_UK
dc.identifier.isiWOS:000784878300040en_UK
dc.identifier.scopusid2-s2.0-85128619540en_UK
dc.identifier.wtid1812128en_UK
dc.contributor.orcid0000-0003-1626-7458en_UK
dc.date.accepted2022-04-01en_UK
dcterms.dateAccepted2022-04-01en_UK
dc.date.filedepositdate2022-05-03en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorVelázquez-Wallraf, Alicia|en_UK
local.rioxx.authorFernández, Antonio|en_UK
local.rioxx.authorCaballero, Maria Jose|en_UK
local.rioxx.authorArregui, Marina|en_UK
local.rioxx.authorGonzález Díaz, Óscar|en_UK
local.rioxx.authorBetancor, Monica B|0000-0003-1626-7458en_UK
local.rioxx.authorBernaldo de Quirós, Yara|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2022-05-03en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by/4.0/|2022-05-03|en_UK
local.rioxx.filenames41598-022-10539-8.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source2045-2322en_UK
Appears in Collections:Aquaculture Journal Articles

Files in This Item:
File Description SizeFormat 
s41598-022-10539-8.pdfFulltext - Published Version2.55 MBAdobe PDFView/Open


This item is protected by original copyright



A file in this item is licensed under a Creative Commons License Creative Commons

Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

The metadata of the records in the Repository are available under the CC0 public domain dedication: No Rights Reserved https://creativecommons.org/publicdomain/zero/1.0/

If you believe that any material held in STORRE infringes copyright, please contact library@stir.ac.uk providing details and we will remove the Work from public display in STORRE and investigate your claim.