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Appears in Collections:Biological and Environmental Sciences Journal Articles
Peer Review Status: Refereed
Title: Propionic Acid Promotes the Virulent Phenotype of Crohn’s Disease-Associated Adherent-Invasive Escherichia coli
Author(s): Ormsby, Michael J
Johnson, Síle A
Carpena, Nuria
Meikle, Lynsey M
Goldstone, Robert J
McIntosh, Anne
Wessel, Hannah M
Hulme, Heather E
McConnachie, Ceilidh C
Connolly, James P R
Roe, Andrew J
Hasson, Conor
Boyd, Joseph
Fitzgerald, Eamonn
Gerasimidis, Konstantinos
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Keywords: Crohn's disease
adherent-invasive E. coli
propionic acid
short chain fatty acid
Issue Date: Feb-2020
Date Deposited: 25-Nov-2021
Citation: Ormsby MJ, Johnson SA, Carpena N, Meikle LM, Goldstone RJ, McIntosh A, Wessel HM, Hulme HE, McConnachie CC, Connolly JPR, Roe AJ, Hasson C, Boyd J, Fitzgerald E & Gerasimidis K (2020) Propionic Acid Promotes the Virulent Phenotype of Crohn’s Disease-Associated Adherent-Invasive Escherichia coli. Cell Reports, 30 (7), pp. 2297-2305.e5.
Abstract: The short chain fatty acid propionic acid is a bacterium-derived human intestinal antimicrobial and immune modulator used widely in Western food production and agriculture. Here, Ormsby et al. demonstrate that exposure to propionic acid induces virulence-associated phenotypic changes in Crohn's disease-associated adherent-invasive Escherichia coli (AIEC).
DOI Link: 10.1016/J.CELREP.2020.01.078
Rights: © 2020 The Author(s). This is an open access article distributed under the terms of the Creative Commons CC-BY license (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You are not required to obtain permission to reuse this article.
Notes: Additional co-authors: Douglas Morrison, Georgina L. Hold, Richard Hansen, Daniel Walker, David G.E. Smith, Daniel M. Wall
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