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http://hdl.handle.net/1893/31975| Appears in Collections: | Aquaculture Journal Articles |
| Peer Review Status: | Refereed |
| Title: | Intrasarcoplasmic Polyglucosan Inclusions in Heart and Skeletal Muscles of Long-Finned Pilot Whales (Globicephala melas) may be Age-Related |
| Author(s): | Longué, Camille Dagleish, Mark McGovern, Gillian Brownlow, Andrew Baily, Johanna |
| Contact Email: | j.l.baily@stir.ac.uk |
| Keywords: | cetacean myopathy non-pathogenic polyglucosan inclusions |
| Issue Date: | Nov-2020 |
| Date Deposited: | 18-Nov-2020 |
| Citation: | Longué C, Dagleish M, McGovern G, Brownlow A & Baily J (2020) Intrasarcoplasmic Polyglucosan Inclusions in Heart and Skeletal Muscles of Long-Finned Pilot Whales (Globicephala melas) may be Age-Related. Journal of Comparative Pathology, 181, pp. 18-25. https://doi.org/10.1016/j.jcpa.2020.09.011 |
| Abstract: | Polysaccharide storage myopathies have been described in several animal species and are characterized by periodic acid–Schiff (PAS)-positive, diastase-resistant intrasarcoplasmic inclusions in myocytes. Skeletal and cardiac muscle samples from a subset of a single pod of stranded long-finned pilot whales (Globicephala melas) were evaluated by light and transmission electron microscopy. Twelve individuals demonstrated sporadic basophilic packets of PAS-positive, diastase-resistant complex polysaccharide material, either centrally or peripherally, in skeletal and cardiac myocytes. Few microscopic myopathic changes were found but included focal inflammation and internalized nuclei. Ultrastructurally, the inclusions consisted of loosely arranged, tangled filaments and were not membrane-bound, which is consistent with polyglucosan inclusions. Within skeletal muscle, the number of inclusions had a marginal statistically significant (P = 0.0536) correlation with length, as a proxy for age, suggesting that such inclusions in skeletal muscles may be age-related, although the cause remains unclear. |
| DOI Link: | 10.1016/j.jcpa.2020.09.011 |
| Rights: | This item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. Accepted refereed manuscript of: Longué C, Dagleish M, McGovern G, Brownlow A & Baily J (2020) Intrasarcoplasmic Polyglucosan Inclusions in Heart and Skeletal Muscles of Long-Finned Pilot Whales (Globicephala melas) may be Age-Related. Journal of Comparative Pathology, 181, pp. 18-25. https://doi.org/10.1016/j.jcpa.2020.09.011 © 2020, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| Licence URL(s): | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| YJCPA-D-20-00191R1 Final draft submission.pdf | Fulltext - Accepted Version | 705.79 kB | Adobe PDF | View/Open |
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