Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/31879
Appears in Collections:Computing Science and Mathematics Journal Articles
Peer Review Status: Refereed
Title: The Relationship between AKI and CKD in Patients with Type 2 Diabetes: An Observational Cohort Study
Author(s): Hapca, Simona
Siddiqui, Moneeza K
Kwan, Ryan S Y
Lim, Michelle
Matthew, Shona
Doney, Alex S F
Pearson, Ewan R
Palmer, Colin N A
Bell, Samira
Keywords: chronic kidney disease
diabetes mellitus
epidemiology and outcomes
acute kidney injury
Issue Date: Jan-2021
Date Deposited: 27-Oct-2020
Citation: Hapca S, Siddiqui MK, Kwan RSY, Lim M, Matthew S, Doney ASF, Pearson ER, Palmer CNA & Bell S (2021) The Relationship between AKI and CKD in Patients with Type 2 Diabetes: An Observational Cohort Study. Journal of the American Society of Nephrology, 32 (1), pp. 138-150. https://doi.org/10.1681/asn.2020030323
Abstract: Background There are few observational studies evaluating the risk of AKI in people with type 2 diabetes, and even fewer simultaneously investigating AKI and CKD in this population. This limits understanding of the interplay between AKI and CKD in people with type 2 diabetes compared with the nondiabetic population. Methods In this retrospective, cohort study of participants with or without type 2 diabetes, we used electronic healthcare records to evaluate rates of AKI and various statistical methods to determine their relationship to CKD status and further renal function decline. Results We followed the cohort of 16,700 participants (9417 with type 2 diabetes and 7283 controls without diabetes) for a median of 8.2 years. Those with diabetes were more likely than controls to develop AKI (48.6% versus 17.2%, respectively) and have preexisting CKD or CKD that developed during follow-up (46.3% versus 17.2%, respectively). In the absence of CKD, the AKI rate among people with diabetes was nearly five times that of controls (121.5 versus 24.6 per 1000 person-years). Among participants with CKD, AKI rate in people with diabetes was more than twice that of controls (384.8 versus 180.0 per 1000 person-years after CKD diagnostic date, and 109.3 versus 47.4 per 1000 person-years before CKD onset in those developing CKD after recruitment). Decline in eGFR slope before AKI episodes was steeper in people with diabetes versus controls. After AKI episodes, decline in eGFR slope became steeper in people without diabetes, but not among those with diabetes and preexisting CKD. Conclusions Patients with diabetes have significantly higher rates of AKI compared with patients without diabetes, and this remains true for individuals with preexisting CKD.
DOI Link: 10.1681/asn.2020030323
Rights: [JASN_AKI_CKD_supplemenatry_material_22072020.pdf] The Relationship between AKI and CKD in Patients with Type 2 Diabetes: An Observational Cohort Study, Simona Hapca, Moneeza K. Siddiqui, Ryan S.Y. Kwan, Michelle Lim, Shona Matthew, Alex S.F. Doney, Ewan R. Pearson, Colin N.A. Palmer, Samira Bell, on behalf of the BEAt-DKD Consortium*, JASN Oct 2020, ASN.2020030323; DOI: 10.1681/ASN.2020030323
[AKI_CKD_JASN_final27072020.pdf] The Relationship between AKI and CKD in Patients with Type 2 Diabetes: An Observational Cohort Study, Simona Hapca, Moneeza K. Siddiqui, Ryan S.Y. Kwan, Michelle Lim, Shona Matthew, Alex S.F. Doney, Ewan R. Pearson, Colin N.A. Palmer, Samira Bell, on behalf of the BEAt-DKD Consortium*, JASN Jan 2020, vol. 32 no. 1, pp. 138-150; DOI: 10.1681/ASN.2020030323
Notes: on behalf of the BEAt-DKD Consortium
Licence URL(s): https://storre.stir.ac.uk/STORREEndUserLicence.pdf

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