Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/31801
Appears in Collections:Psychology Journal Articles
Peer Review Status: Refereed
Title: Early-life adversity accelerates cellular ageing and affects adult inflammation: Experimental evidence from the European starling
Author(s): Nettle, Daniel
Andrews, Clare
Reichert, Sophie
Bedford, Tom
Kolenda, Claire
Parker, Craig
Martin-Ruiz, Carmen
Monaghan, Pat
Bateson, Melissa
Keywords: Ageing
Behavioural ecology
Biomarkers
Issue Date: Feb-2017
Date Deposited: 9-Oct-2020
Citation: Nettle D, Andrews C, Reichert S, Bedford T, Kolenda C, Parker C, Martin-Ruiz C, Monaghan P & Bateson M (2017) Early-life adversity accelerates cellular ageing and affects adult inflammation: Experimental evidence from the European starling. Scientific Reports, 7 (1), Art. No.: 40794. https://doi.org/10.1038/srep40794
Abstract: Early-life adversity is associated with accelerated cellular ageing during development and increased inflammation during adulthood. However, human studies can only establish correlation, not causation, and existing experimental animal approaches alter multiple components of early-life adversity simultaneously. We developed a novel hand-rearing paradigm in European starling nestlings (Sturnus vulgaris), in which we separately manipulated nutritional shortfall and begging effort for a period of 10 days. The experimental treatments accelerated erythrocyte telomere attrition and increased DNA damage measured in the juvenile period. For telomere attrition, amount of food and begging effort exerted additive effects. Only the combination of low food amount and high begging effort increased DNA damage. We then measured two markers of inflammation, high-sensitivity C-reactive protein and interleukin-6, when the birds were adults. The experimental treatments affected both inflammatory markers, though the patterns were complex and different for each marker. The effect of the experimental treatments on adult interleukin-6 was partially mediated by increased juvenile DNA damage. Our results show that both nutritional input and begging effort in the nestling period affect cellular ageing and adult inflammation in the starling. However, the pattern of effects is different for different biomarkers measured at different time points.
DOI Link: 10.1038/srep40794
Rights: This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
Licence URL(s): http://creativecommons.org/licenses/by/4.0/

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