Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/31764
Appears in Collections:Psychology Journal Articles
Peer Review Status: Refereed
Title: Dissociating the effects of alternative early-life feeding schedules on the development of adult depression-like phenotypes
Author(s): Neville, Vikki
Andrews, Clare
Nettle, Daniel
Bateson, Melissa
Issue Date: Dec-2017
Date Deposited: 30-Sep-2020
Citation: Neville V, Andrews C, Nettle D & Bateson M (2017) Dissociating the effects of alternative early-life feeding schedules on the development of adult depression-like phenotypes. Scientific Reports, 7 (1), Art. No.: 14832. https://doi.org/10.1038/s41598-017-13776-4
Abstract: Early-life adversity is associated with increased vulnerability to depression in humans, and depression-like phenotypes in animals. However, different types of adverse experience may leave different signatures in adulthood. We experimentally manipulated the Amount of food delivered to European starling nestlings and the begging Effort required to obtain food during early development. Here, we report behavioural data in adulthood from a task that assessed sensitivity to shifts in reward magnitude characteristic of depression-like low mood. Birds that had experienced Hard Effort were more food motivated than birds that had experienced Easy Effort. Both Effort and Amount affected sensitivity to shifts in reward magnitude: Hard Effort birds showed an enhanced negative contrast effect following loss of reward (‘disappointment’), and Lean Amount birds failed to show a normal positive contrast effect following gain in reward (a lack of ‘elation’). Therefore, the feeding schedule experienced for just 10 days in early life caused enduring effects on feeding motivation and sensitivity to reward loss/gain consistent with human depression. Furthermore, the contrast effects were specific to different types of adversity. These results highlight the importance of early-life feeding schedules in the development of depression-like phenotypes.
DOI Link: 10.1038/s41598-017-13776-4
Rights: This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
Licence URL(s): http://creativecommons.org/licenses/by/4.0/

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