Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/31576
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dc.contributor.authorParma, Valentinaen_UK
dc.contributor.authorOhla, Kathrinen_UK
dc.contributor.authorVeldhuizen, Maria Gen_UK
dc.contributor.authorNiv, Masha Yen_UK
dc.contributor.authorKelly, Christine Een_UK
dc.contributor.authorBakke, Alyssa Jen_UK
dc.contributor.authorCooper, Keiland Wen_UK
dc.contributor.authorBouysset, Cédricen_UK
dc.contributor.authorPirastu, Nicolaen_UK
dc.contributor.authorDibattista, Micheleen_UK
dc.contributor.authorKaur, Rishemjiten_UK
dc.contributor.authorLiuzza, Marco Tullioen_UK
dc.contributor.authorPepino, Marta Yen_UK
dc.contributor.authorSchöpf, Veronikaen_UK
dc.contributor.authorRoberts, S Craigen_UK
dc.date.accessioned2020-08-19T00:02:05Z-
dc.date.available2020-08-19T00:02:05Z-
dc.date.issued2020-09en_UK
dc.identifier.urihttp://hdl.handle.net/1893/31576-
dc.description.abstractRecent anecdotal and scientific reports have provided evidence of a link between COVID-19 and chemosensory impairments such as anosmia. However, these reports have downplayed or failed to distinguish potential effects on taste, ignored chemesthesis, generally lacked quantitative measurements, were mostly restricted to data from single countries. Here, we report the development, implementation and initial results of a multi-lingual, international questionnaire to assess self-reported quantity and quality of perception in three distinct chemosensory modalities (smell, taste, and chemesthesis) before and during COVID-19. In the first 11 days after questionnaire launch, 4039 participants (2913 women, 1118 men, 8 other, ages 19-79) reported a COVID-19 diagnosis either via laboratory tests or clinical assessment. Importantly, smell, taste and chemesthetic function were each significantly reduced compared to their status before the disease. Difference scores (maximum possible change+/-100) revealed a mean reduction of smell (-79.7+/- 28.7, mean+/- SD), taste (-69.0+/- 32.6), and chemesthetic (-37.3+/- 36.2) function during COVID-19. Qualitative changes in olfactory ability (parosmia and phantosmia) were relatively rare and correlated with smell loss. Importantly, perceived nasal obstruction did not account for smell loss. Furthermore, chemosensory impairments were similar between participants in the laboratory test and clinical assessment groups. These results show that COVID-19-associated chemosensory impairment is not limited to smell, but also affects taste and chemesthesis. The multimodal impact of COVID-19 and lack of perceived nasal obstruction suggest that SARS-CoV-2 infection may disrupt sensory-neural mechanisms.en_UK
dc.language.isoenen_UK
dc.publisherOxford University Pressen_UK
dc.relationParma V, Ohla K, Veldhuizen MG, Niv MY, Kelly CE, Bakke AJ, Cooper KW, Bouysset C, Pirastu N, Dibattista M, Kaur R, Liuzza MT, Pepino MY, Schöpf V & Roberts SC (2020) More than smell - COVID-19 is associated with severe impairment of smell, taste, and chemesthesis. Chemical Senses, 45 (7), pp. 609-622. https://doi.org/10.1093/chemse/bjaa041en_UK
dc.rightsThis item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. This is a pre-copyedited, author-produced PDF of an article accepted for publication in Chemical Senses following peer review. The version of record Parma V, Ohla K, Veldhuizen MG, et. al. (2020) More than smell. COVID-19 is associated with severe impairment of smell, taste, and chemesthesis. Chemical Senses, Volume 45, Issue 7, September 2020, Pages 609–622 is available online at: https://doi.org/10.1093/chemse/bjaa041en_UK
dc.rights.urihttps://storre.stir.ac.uk/STORREEndUserLicence.pdfen_UK
dc.titleMore than smell - COVID-19 is associated with severe impairment of smell, taste, and chemesthesisen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2021-06-21en_UK
dc.rights.embargoreason[bjaa041.pdf] Publisher requires embargo of 12 months after formal publication.en_UK
dc.identifier.doi10.1093/chemse/bjaa041en_UK
dc.identifier.pmid32564071en_UK
dc.citation.jtitleChemical Sensesen_UK
dc.citation.issn1464-3553en_UK
dc.citation.issn0379-864Xen_UK
dc.citation.volume45en_UK
dc.citation.issue7en_UK
dc.citation.spage609en_UK
dc.citation.epage622en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.author.emailcraig.roberts@stir.ac.uken_UK
dc.citation.date20/06/2020en_UK
dc.description.notesAdditional co-authors: Veronica Pereda-Loth, Shannon B Olsson, Richard C Gerkin, Paloma Rohlfs Domínguez, Javier Albayay, Michael C. Farruggia, Surabhi Bhutani, Alexander W Fjaeldstad, Ritesh Kumar, Anna Menini, Moustafa Bensafi, Mari Sandell, Iordanis Konstantinidis, Antonella Di Pizio, Federica Genovese, Lina Öztürk, Thierry Thomas-Danguin, Johannes Frasnelli, Sanne Boesveldt, Özlem Saatci, Luis R. Saraiva, Cailu Lin, Jérôme Golebiowski, Liang-Dar Hwang, Mehmet Hakan Ozdener, Maria Dolors Guàrdia, Christophe Laudamiel, Marina Ritchie, Jan Havlícek, Denis Pierron, Eugeni Roura, Marta Navarro, Alissa A. Nolden, Juyun Lim, KL Whitcroft, Lauren R. Colquitt, Camille Ferdenzi, Evelyn V. Brindha, Aytug Altundag, Alberto Macchi, Alexia Nunez-Parra, Zara M. Patel, Sébastien Fiorucci, Carl M. Philpott, Barry C. Smith, Johan N Lundström, Carla Mucignat, Jane K. Parker, Mirjam van den Brink, Michael Schmuker, Florian Ph.S Fischmeister, Thomas Heinbockel, Vonnie D.C. Shields, Farhoud Faraji, Enrique Enrique Santamaría, William E.A. Fredborg, Gabriella Morini, Jonas K. Olofsson, Maryam Jalessi, Noam Karni, Anna D'Errico, Rafieh Alizadeh, Robert Pellegrino, Pablo Meyer, Caroline Huart, Ben Chen, Graciela M. Soler, Mohammed K. Alwashahi, Olagunju Abdulrahman, Antje Welge-Lüssen, Pamela Dalton, Jessica Freiherr, Carol H. Yan, Jasper H. B. de Groot, Vera V. Voznessenskaya, Hadar Klein, Jingguo Chen, Masako Okamoto, Elizabeth A. Sell, Preet Bano Singh, Julie Walsh-Messinger, Nicholas S. Archer, Sachiko Koyama, Vincent Deary, Hüseyin Yanik, Samet Albayrak, Lenka Martinec Novákov, Ilja Croijmans, Patricia Portillo Mazal, Shima T. Moein, Eitan Margulis, Coralie Mignot, Sajidxa Mariño, Dejan Georgiev, Pavan K. Kaushik, Bettina Malnic, Hong Wang, Shima Seyed-Allaei, Nur Yoluk, Sara Razzaghi, Jeb M. Justice, Diego Restrepo, Julien W Hsieh, Danielle R. Reed, Thomas Hummel, Steven D Munger, John E Hayesen_UK
dc.contributor.affiliationTemple Universityen_UK
dc.contributor.affiliationForschungszentrum Julichen_UK
dc.contributor.affiliationMersin Universityen_UK
dc.contributor.affiliationHebrew University of Jerusalemen_UK
dc.contributor.affiliationAbScenten_UK
dc.contributor.affiliationPenn State Universityen_UK
dc.contributor.affiliationUniversity of California, Irvineen_UK
dc.contributor.affiliationUniversity of Côte d'Azuren_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Bari, Italyen_UK
dc.contributor.affiliationMinistry of Science and Technology, Indiaen_UK
dc.contributor.affiliationMagnia Graecia Universityen_UK
dc.contributor.affiliationUniversity of Illinois at Urbana-Champaign, USAen_UK
dc.contributor.affiliationMedical University of Viennaen_UK
dc.contributor.affiliationPsychologyen_UK
dc.identifier.isiWOS:000591530900014en_UK
dc.identifier.scopusid2-s2.0-85092628123en_UK
dc.identifier.wtid1626166en_UK
dc.contributor.orcid0000-0003-0276-7072en_UK
dc.contributor.orcid0000-0002-0358-9645en_UK
dc.contributor.orcid0000-0002-9641-6101en_UK
dc.date.accepted2020-06-10en_UK
dcterms.dateAccepted2020-06-10en_UK
dc.date.filedepositdate2020-08-18en_UK
dc.subject.tagCOVID-19en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionAMen_UK
local.rioxx.authorParma, Valentina|0000-0003-0276-7072en_UK
local.rioxx.authorOhla, Kathrin|en_UK
local.rioxx.authorVeldhuizen, Maria G|en_UK
local.rioxx.authorNiv, Masha Y|en_UK
local.rioxx.authorKelly, Christine E|en_UK
local.rioxx.authorBakke, Alyssa J|en_UK
local.rioxx.authorCooper, Keiland W|0000-0002-0358-9645en_UK
local.rioxx.authorBouysset, Cédric|en_UK
local.rioxx.authorPirastu, Nicola|en_UK
local.rioxx.authorDibattista, Michele|en_UK
local.rioxx.authorKaur, Rishemjit|en_UK
local.rioxx.authorLiuzza, Marco Tullio|en_UK
local.rioxx.authorPepino, Marta Y|en_UK
local.rioxx.authorSchöpf, Veronika|en_UK
local.rioxx.authorRoberts, S Craig|0000-0002-9641-6101en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2021-06-21en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||2021-06-20en_UK
local.rioxx.licencehttps://storre.stir.ac.uk/STORREEndUserLicence.pdf|2021-06-21|en_UK
local.rioxx.filenamebjaa041.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1464-3553en_UK
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