Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/31287
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dc.contributor.authorVoormolen, Daphne Cen_UK
dc.contributor.authorZeldovich, Marinaen_UK
dc.contributor.authorHaagsma, Juanita Aen_UK
dc.contributor.authorPolinder, Suzanneen_UK
dc.contributor.authorFriedrich, Sarahen_UK
dc.contributor.authorMaas, Andrew I Ren_UK
dc.contributor.authorWilson, Lindsayen_UK
dc.contributor.authorSteyerberg, Ewout Wen_UK
dc.contributor.authorCovic, Amraen_UK
dc.contributor.authorAndelic, Nadaen_UK
dc.contributor.authorPlass, Anne Marieen_UK
dc.contributor.authorWu, Yi-Jhenen_UK
dc.contributor.authorAsendorf, Thomasen_UK
dc.contributor.authorvon Steinbüechel, Nicoleen_UK
dc.date.accessioned2020-06-16T14:54:52Z-
dc.date.available2020-06-16T14:54:52Z-
dc.date.issued2020-05en_UK
dc.identifier.other1525en_UK
dc.identifier.urihttp://hdl.handle.net/1893/31287-
dc.description.abstractThe objective of this study was to provide a comprehensive examination of the relation of complicated and uncomplicated mild traumatic brain injury (mTBI) with multidimensional outcomes at three- and six-months after TBI. We analyzed data from the Collaborative European NeuroTrauma Effectiveness Research (CENTER-TBI) research project. Patients after mTBI (Glasgow Coma scale (GCS) score of 13–15) enrolled in the study were differentiated into two groups based on computed tomography (CT) findings: complicated mTBI (presence of any traumatic intracranial injury on first CT) and uncomplicated mTBI (absence of any traumatic intracranial injury on first CT). Multidimensional outcomes were assessed using seven instruments measuring generic and disease-specific health-related quality of life (HRQoL) (SF-36 and QOLIBRI), functional outcome (GOSE), and psycho-social domains including symptoms of post-traumatic stress disorder (PTSD) (PCL-5), depression (PHQ-9), and anxiety (GAD-7). Data were analyzed using a multivariate repeated measures approach (MANOVA-RM), which inspected mTBI groups at three- and six-months post injury. Patients after complicated mTBI had significantly lower GOSE scores, reported lower physical and mental component summary scores based on the SF-36 version 2, and showed significantly lower HRQoL measured by QOLIBRI compared to those after uncomplicated mTBI. There was no difference between mTBI groups when looking at psychological outcomes, however, a slight improvement in PTSD symptoms and depression was observed for the entire sample from three to six months. Patients after complicated mTBI reported lower generic and disease specific HRQoL and worse functional outcome compared to individuals after uncomplicated mTBI at three and six months. Both groups showed a tendency to improve from three to six months after TBI. The complicated mTBI group included more patients with an impaired long-term outcome than the uncomplicated group. Nevertheless, patients, clinicians, researchers, and decisions-makers in health care should take account of the short and long-term impact on outcome for patients after both uncomplicated and complicated mTBI.en_UK
dc.language.isoenen_UK
dc.publisherMDPIen_UK
dc.relationVoormolen DC, Zeldovich M, Haagsma JA, Polinder S, Friedrich S, Maas AIR, Wilson L, Steyerberg EW, Covic A, Andelic N, Plass AM, Wu Y, Asendorf T & von Steinbüechel N (2020) Outcomes after Complicated and Uncomplicated Mild Traumatic Brain Injury at Three- and Six-Months Post-Injury: Results from the CENTER-TBI Study. Journal of Clinical Medicine, 9 (5), Art. No.: 1525. https://doi.org/10.3390/jcm9051525en_UK
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly citeden_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.subjectTraumatic brain injuryen_UK
dc.subjectoutcomeen_UK
dc.subjectgeneric and disease-specific health-related quality of lifeen_UK
dc.subjectcomplicated mild traumatic brain injuryen_UK
dc.subjectfunctional outcomeen_UK
dc.titleOutcomes after Complicated and Uncomplicated Mild Traumatic Brain Injury at Three- and Six-Months Post-Injury: Results from the CENTER-TBI Studyen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.3390/jcm9051525en_UK
dc.identifier.pmid32443573en_UK
dc.citation.jtitleJournal of Clinical Medicineen_UK
dc.citation.issn2077-0383en_UK
dc.citation.volume9en_UK
dc.citation.issue5en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderEuropean Commission (Horizon 2020)en_UK
dc.citation.date18/05/2020en_UK
dc.contributor.affiliationErasmus MC Rotterdamen_UK
dc.contributor.affiliationGeorg-August University Gottingenen_UK
dc.contributor.affiliationErasmus MC Rotterdamen_UK
dc.contributor.affiliationErasmus MC Rotterdamen_UK
dc.contributor.affiliationGeorg-August University Gottingenen_UK
dc.contributor.affiliationUniversity of Antwerpen_UK
dc.contributor.affiliationPsychologyen_UK
dc.contributor.affiliationErasmus MC Rotterdamen_UK
dc.contributor.affiliationGeorg-August University Gottingenen_UK
dc.contributor.affiliationUniversity of Osloen_UK
dc.contributor.affiliationGeorg-August University Gottingenen_UK
dc.contributor.affiliationGeorg-August University Gottingenen_UK
dc.contributor.affiliationGeorg-August University Gottingenen_UK
dc.contributor.affiliationGeorg-August University Gottingenen_UK
dc.identifier.isiWOS:000540223800282en_UK
dc.identifier.wtid1630412en_UK
dc.contributor.orcid0000-0003-4113-2328en_UK
dc.date.accepted2020-05-15en_UK
dcterms.dateAccepted2020-05-15en_UK
dc.date.filedepositdate2020-06-16en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorVoormolen, Daphne C|en_UK
local.rioxx.authorZeldovich, Marina|en_UK
local.rioxx.authorHaagsma, Juanita A|en_UK
local.rioxx.authorPolinder, Suzanne|en_UK
local.rioxx.authorFriedrich, Sarah|en_UK
local.rioxx.authorMaas, Andrew I R|en_UK
local.rioxx.authorWilson, Lindsay|0000-0003-4113-2328en_UK
local.rioxx.authorSteyerberg, Ewout W|en_UK
local.rioxx.authorCovic, Amra|en_UK
local.rioxx.authorAndelic, Nada|en_UK
local.rioxx.authorPlass, Anne Marie|en_UK
local.rioxx.authorWu, Yi-Jhen|en_UK
local.rioxx.authorAsendorf, Thomas|en_UK
local.rioxx.authorvon Steinbüechel, Nicole|en_UK
local.rioxx.projectProject ID unknown|European Commission (Horizon 2020)|en_UK
local.rioxx.freetoreaddate2020-06-16en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by/4.0/|2020-06-16|en_UK
local.rioxx.filenamejcm-09-01525-v2.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source2077-0383en_UK
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