|Appears in Collections:||Aquaculture Journal Articles|
|Peer Review Status:||Refereed|
|Title:||Salmon immunological defense and interplay with the modulatory capabilities of its ectoparasite Lepeophtheirus salmonis|
|Author(s):||Braden, Laura M|
Monaghan, Sean J
Fast, Mark D
|Citation:||Braden LM, Monaghan SJ & Fast MD (2020) Salmon immunological defense and interplay with the modulatory capabilities of its ectoparasite Lepeophtheirus salmonis. Parasite Immunology. https://doi.org/10.1111/pim.12731|
|Abstract:||The salmon louse Lepeophtheirus salmonis (Lsal ) is an ectoparasitic copepod that exerts immunomodulatory and physiological effects on its host Atlantic salmon. Over 30 years of research on louse biology, control, host responses and the host‐parasite relationship has provided a plethora of information on the intricacies of host resistance and parasite adaptation. Atlantic salmon exhibit temporal and spatial impairment of the immune system and wound healing ability during infection. This immunosuppression may render Atlantic salmon less tolerant to stress and other confounders associated with current management strategies. Contrasting susceptibility of salmonid hosts exists and early pro‐inflammatory Th1 type responses are associated with resistance. Rapid cellular responses to larvae appear to tip the balance of the host‐parasite relationship in favour of the host, preventing severe immune‐physiological impacts of the more invasive adults. Immunological, transcriptomic, genomic and proteomic evidence suggests pathological impacts occur in susceptible hosts through modulation of host immunity and physiology via pharmacologically active molecules. Co‐evolutionary and farming selection pressures may have incurred preference of Atlantic salmon as a host for Lsal reflected in their interactome. Here we review host‐parasite interactions at the primary attachment/feeding site, and the complex life‐stage dependent molecular mechanisms employed to subvert host physiology and immune responses.|
|Rights:||This item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.|
|Notes:||Output Status: Forthcoming/Available Online|
|Braden et al 2020 - REVIEW - Sea lice immunmodulation.pdf||Fulltext - Accepted Version||10.17 MB||Adobe PDF||Under Embargo until 2021-05-14 Request a copy|
Note: If any of the files in this item are currently embargoed, you can request a copy directly from the author by clicking the padlock icon above. However, this facility is dependent on the depositor still being contactable at their original email address.
This item is protected by original copyright
Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
If you believe that any material held in STORRE infringes copyright, please contact email@example.com providing details and we will remove the Work from public display in STORRE and investigate your claim.