Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/30911
Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Dietary fenofibrate attenuated high-fat-diet-induced lipid accumulation and inflammation response partly through regulation of pparα and sirt1 in juvenile black seabream (Acanthopagrus schlegelii)
Author(s): Jin, Min
Zhu, Tingting
Tocher, Douglas
Luo, Jiaxiang
Shen, Yuedong
Li, Xuejiao
Pan, Tingting
Yuan, Ye
Betancor, Monica
Jiao, Lefei
Sun, Peng
Zhou, Quicun
Contact Email: m.b.betancor@stir.ac.uk
Keywords: fenofibrate
high-fat diet
inflammation response
pparα
sirt1
Issue Date: Aug-2020
Citation: Jin M, Zhu T, Tocher D, Luo J, Shen Y, Li X, Pan T, Yuan Y, Betancor M, Jiao L, Sun P & Zhou Q (2020) Dietary fenofibrate attenuated high-fat-diet-induced lipid accumulation and inflammation response partly through regulation of pparα and sirt1 in juvenile black seabream (Acanthopagrus schlegelii). Developmental and Comparative Immunology, 109, Art. No.: 103691. https://doi.org/10.1016/j.dci.2020.103691
Abstract: An 8-week feeding trail was conducted in Acanthopagrus schlegelii with an initial body weight of 8.34±0.01g. Three isonitrogenous diets were formulated, (1) Control: medium-fat diet (12%); (2) HFD: high-fat diet (18%); (3) HFD+FF: high-fat diet with fenofibrate (0.15%). Liver histological analysis revealed that, compared to HFD, vacuolar fat drops were smaller and fewer in fish fed fenofibrate. Expression of lipid catabolism regulator peroxisome proliferator-activated receptor alpha (pparα) was up-regulated by fenofibrate compared with HFD. In addition, fenofibrate significantly increased the expression level of silent information regulator 1 (sirt1). Meanwhil e, the expression level of anti-inflammatory cytokine interleukin 10 (il-10) in intestine was up-regulated, while pro-inflammatory cytokine interleukin 1β (il-1β) in liver and intestine were down-regulated by dietary fenofibrate supplementation. Overall, the present study indicated that fenofibrate reduced fat deposition and attenuated inflammation response caused by HFD partly through a pathway involving regulation of pparα and sirt1.
DOI Link: 10.1016/j.dci.2020.103691
Rights: This item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. Accepted refereed manuscript of: Jin M, Zhu T, Tocher D, Luo J, Shen Y, Li X, Pan T, Yuan Y, Betancor M, Jiao L, Sun P & Zhou Q (2020) Dietary fenofibrate attenuated high-fat-diet-induced lipid accumulation and inflammation response partly through regulation of pparα and sirt1 in juvenile black seabream (Acanthopagrus schlegelii). Developmental and Comparative Immunology, 109, Art. No.: 103691. DOI: https://doi.org/10.1016/j.dci.2020.103691 © 2020, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/
Licence URL(s): http://creativecommons.org/licenses/by-nc-nd/4.0/

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