Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/30507
Appears in Collections:Psychology Journal Articles
Peer Review Status: Refereed
Title: Major histocompatibility complex-associated odour preferences and human mate choice: near and far horizons
Author(s): Havlicek, Jan
Winternitz, Jamie
Roberts, S Craig
Contact Email: craig.roberts@stir.ac.uk
Keywords: HLA
complementary genes
inbreeding
sexual selection
attractiveness
body odour
Issue Date: Jun-2020
Citation: Havlicek J, Winternitz J & Roberts SC (2020) Major histocompatibility complex-associated odour preferences and human mate choice: near and far horizons. Philosophical Transactions of the Royal Society B: Biological Sciences, 375 (1800), Art. No.: 20190260. https://doi.org/10.1098/rstb.2019.0260
Abstract: The major histocompatibility complex (MHC) is a core part of the adaptive immune system. As in other vertebrate taxa, it may also affect human chemical communication via odour-based mate preferences, with greater attraction towards MHC-dissimilar partners. However, despite some well-known findings, the available evidence is equivocal and made complicated by varied approaches to quantifying human mate choice. To address this, we here conduct comprehensive meta-analyses focusing on studies assessing i] genomic mate selection, ii] relationship satisfaction and iii] odour preference. Analysis of genomic studies reveals no association between MHC-dissimilarity and mate choice in actual couples; however, MHC effects appear to be independent of genomic background. The effect of MHC-dissimilarity on relationship satisfaction was not significant and we found evidence for publication bias in studies on this area. There was also no significant association between MHC-dissimilarity and odour preferences. Finally, combining effect sizes from all genomic, relationship satisfaction, odour preference and previous mate choice studies into an overall estimate showed no overall significant effect of MHC similarity on human mate selection. Based on these findings, we make a set of recommendations for future studies, focusing both on aspects that should be implemented immediately and those that lurk on the far horizon. We need larger samples with greater geographical and cultural diversity, that control for genome-wide similarity. We also need more focus on mechanisms of MHC-associated odour preferences and on MHC-associated pregnancy loss.
DOI Link: 10.1098/rstb.2019.0260
Rights: Publisher policy allows this work to be made available in this repository. Published in Philosophical Transactions of the Royal Society B: Biological Sciences. The original publication is available at: https://doi.org.10.1098/rstb.2019.0260

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