Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/30493
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dc.contributor.authorJin, Minen_UK
dc.contributor.authorPan, Tingtingen_UK
dc.contributor.authorTocher, Douglasen_UK
dc.contributor.authorBetancor, Monicaen_UK
dc.contributor.authorMonroig, Oscaren_UK
dc.contributor.authorShen, Yuedongen_UK
dc.contributor.authorZhu, Tingtingen_UK
dc.contributor.authorSun, Pengen_UK
dc.contributor.authorJiao, Lefeien_UK
dc.contributor.authorZhou, Qicunen_UK
dc.date.accessioned2019-11-22T16:48:22Z-
dc.date.available2019-11-22T16:48:22Z-
dc.date.issued2019en_UK
dc.identifier.othere38en_UK
dc.identifier.urihttp://hdl.handle.net/1893/30493-
dc.description.abstractThe present study aimed to investigate whether dietary choline can regulate lipid metabolism and suppress NFκB activation and, consequently, attenuate inflammation induced by a high-fat diet in black sea bream (Acanthopagrus schlegelii). An 8-week feeding trial was conducted on fish with an initial weight of 8·16 ± 0·01 g. Five diets were formulated: control, low-fat diet (11 %); HFD, high-fat diet (17 %); and HFD supplemented with graded levels of choline (3, 6 or 12 g/kg) termed HFD + C1, HFD + C2 and HFD + C3, respectively. Dietary choline decreased lipid content in whole body and tissues. Highest TAG and cholesterol concentrations in serum and liver were recorded in fish fed the HFD. Similarly, compared with fish fed the HFD, dietary choline reduced vacuolar fat drops and ameliorated HFD-induced pathological changes in liver. Expression of genes of lipolysis pathways were up-regulated, and genes of lipogenesis down-regulated, by dietary choline compared with fish fed the HFD. Expression of nfκb and pro-inflammatory cytokines in liver and intestine was suppressed by choline supplementation, whereas expression of anti-inflammatory cytokines was promoted in fish fed choline-supplemented diets. In fish that received lipopolysaccharide to stimulate inflammatory responses, the expression of nfκb and pro-inflammatory cytokines in liver, intestine and kidney were all down-regulated by dietary choline compared with the HFD. Overall, the present study indicated that dietary choline had a lipid-lowering effect, which could protect the liver by regulating intrahepatic lipid metabolism, reducing lipid droplet accumulation and suppressing NFκB activation, consequently attenuating HFD-induced inflammation in A. schlegelii.en_UK
dc.language.isoenen_UK
dc.publisherNutrition Societyen_UK
dc.relationJin M, Pan T, Tocher D, Betancor M, Monroig O, Shen Y, Zhu T, Sun P, Jiao L & Zhou Q (2019) Dietary choline supplementation attenuated high-fat-diet-induced inflammation through regulation of lipid metabolism and suppression of NFKB activation in juvenile black seabream (Acanthopagrus schlegelii). Journal of Nutritional Science, 8, Art. No.: e38. https://doi.org/10.1017/jns.2019.34en_UK
dc.rightsCOPYRIGHT: © The Author(s) 2019 This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.subjectCholineen_UK
dc.subjectHigh-fat dietsen_UK
dc.subjectLipid metabolismen_UK
dc.subjectInflammationen_UK
dc.subjectNFκBen_UK
dc.titleDietary choline supplementation attenuated high-fat-diet-induced inflammation through regulation of lipid metabolism and suppression of NFKB activation in juvenile black seabream (Acanthopagrus schlegelii)en_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1017/jns.2019.34en_UK
dc.citation.jtitleJournal of Nutritional Scienceen_UK
dc.citation.issn2048-6790en_UK
dc.citation.issn2048-6790en_UK
dc.citation.volume8en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.citation.date22/11/2019en_UK
dc.contributor.affiliationNingbo Universityen_UK
dc.contributor.affiliationNingbo Universityen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquaculture Torre de la Salen_UK
dc.contributor.affiliationNingbo Universityen_UK
dc.contributor.affiliationNingbo Universityen_UK
dc.contributor.affiliationNingbo Universityen_UK
dc.contributor.affiliationNingbo Universityen_UK
dc.contributor.affiliationNingbo Universityen_UK
dc.identifier.wtid1469357en_UK
dc.contributor.orcid0000-0002-8603-9410en_UK
dc.contributor.orcid0000-0003-1626-7458en_UK
dc.date.accepted2019-10-11en_UK
dc.description.refREF Compliant by Deposit in Stirling's Repositoryen_UK
dc.date.filedepositdate2019-11-22en_UK
Appears in Collections:Aquaculture Journal Articles

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