Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/30476
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dc.contributor.authorCameron, Elaineen_UK
dc.contributor.authorRog, Daviden_UK
dc.contributor.authorMcDonnell, Gavinen_UK
dc.contributor.authorOverell, Jamesen_UK
dc.contributor.authorPearson, Owenen_UK
dc.contributor.authorFrench, David Pen_UK
dc.date.accessioned2019-11-19T01:05:56Z-
dc.date.available2019-11-19T01:05:56Z-
dc.date.issued2019-01en_UK
dc.identifier.urihttp://hdl.handle.net/1893/30476-
dc.description.abstractBackground The proportion of people with relapsing-remitting multiple sclerosis prescribed disease modifying treatments (DMTs) in the United Kingdom (UK) is considered low compared with other countries. There are differences in DMT prescription rates between UK nations (England, Wales, Scotland, Northern Ireland). Despite this, there has been little research into decision-making processes and prescribing practices. Objective To investigate views and experiences of neurologists prescribing DMTs and MS specialist nurses to identify factors influencing prescribing. Methods Semi-structured interviews with 18 consultant neurologists and 16 specialist nurses from diverse settings across the four UK nations. Data were analysed using thematic framework analysis. Results Prescribing practices are influenced by organisational prescribing “cultures”, informal “benchmarking” within peer networks, and prior experience with different DMTs. Health professionals differ in their perceptions of benefits and risks of DMTs and personal “thresholds” for discerning relapses and determining eligibility for DMTs. Prescribers in England felt most constrained by guidelines. Conclusion To achieve equity in access to DMTs for people with MS eligible for treatment, there is a need for public discussion acknowledging differences in health professionals’ interpretations of “relapses” and guidelines and perceptions of DMTs, variation in organisational prescribing “cultures”, and whether the prevailing culture sufficiently meets patients’ needs.en_UK
dc.language.isoenen_UK
dc.publisherElsevier BVen_UK
dc.relationCameron E, Rog D, McDonnell G, Overell J, Pearson O & French DP (2019) Factors influencing multiple sclerosis disease-modifying treatment prescribing decisions in the United Kingdom: A qualitative interview study. Multiple Sclerosis and Related Disorders, 27, pp. 378-382. https://doi.org/10.1016/j.msard.2018.11.023en_UK
dc.rightsThis article is available under the Creative Commons CC-BY-NC-ND license (http://creativecommons.org/licenses/BY-NC-ND/4.0/) and permits non-commercial use of the work as published, without adaptation or alteration provided the work is fully attributed. .en_UK
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_UK
dc.subjectMultiple sclerosis, relapsing-remittingen_UK
dc.subjectNeurologistsen_UK
dc.subjectNurse specialistsen_UK
dc.subjectClinical decision-makingen_UK
dc.subjectDrug prescriptionsen_UK
dc.subjectQualitative researchen_UK
dc.titleFactors influencing multiple sclerosis disease-modifying treatment prescribing decisions in the United Kingdom: A qualitative interview studyen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1016/j.msard.2018.11.023en_UK
dc.identifier.pmid30500689en_UK
dc.citation.jtitleMultiple Sclerosis and Related Disordersen_UK
dc.citation.issn2211-0356en_UK
dc.citation.issn2211-0348en_UK
dc.citation.volume27en_UK
dc.citation.spage378en_UK
dc.citation.epage382en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderMultiple Sclerosis Societyen_UK
dc.citation.date22/11/2018en_UK
dc.contributor.affiliationUniversity of Manchesteren_UK
dc.contributor.affiliationSalford Royal NHS Foundation Trusten_UK
dc.contributor.affiliationBelfast Health and Social Care Trusten_UK
dc.contributor.affiliationNHS Greater Glasgow & Clydeen_UK
dc.contributor.affiliationAbertawe Bro Morgannwg University Health Boarden_UK
dc.contributor.affiliationUniversity of Manchesteren_UK
dc.identifier.isiWOS:000455500500067en_UK
dc.identifier.scopusid2-s2.0-85057279930en_UK
dc.identifier.wtid1477154en_UK
dc.contributor.orcid0000-0002-8959-5148en_UK
dc.date.accepted2018-11-20en_UK
dc.description.refREF Eligible with Permitted Exceptionen_UK
dc.date.filedepositdate2019-11-14en_UK
Appears in Collections:Psychology Journal Articles

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