Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/30182
Appears in Collections:Psychology Journal Articles
Peer Review Status: Refereed
Title: Impact of general practice endorsement on the social gradient in uptake in bowel cancer screening
Author(s): Raine, Rosalind
Duffy, Stephen W
Wardle, Jane
Solmi, Francesca
Morris, Stephen
Howe, Rosemary
Kralj-Hans, Ines
Snowball, Julia
Counsell, Nicholas
Moss, Sue
Hackshaw, Allan
von Wagner, Christian
Vart, Gemma
McGregor, Lesley M
Smith, Samuel G
Keywords: cancer epidemiology
cancer screening
colorectal cancer
economics
Issue Date: 2-Feb-2016
Citation: Raine R, Duffy SW, Wardle J, Solmi F, Morris S, Howe R, Kralj-Hans I, Snowball J, Counsell N, Moss S, Hackshaw A, von Wagner C, Vart G, McGregor LM & Smith SG (2016) Impact of general practice endorsement on the social gradient in uptake in bowel cancer screening. British Journal of Cancer, 114, pp. 321-326. https://doi.org/10.1038/bjc.2015.413
Abstract: Background: There is a socioeconomic gradient in the uptake of screening in the English NHS Bowel Cancer Screening Programme (BCSP), potentially leading to inequalities in outcomes. We tested whether endorsement of bowel cancer screening by an individual’s general practice (GP endorsement; GPE) reduced this gradient. Methods: A cluster-randomised controlled trial. Over 20 days, individuals eligible for screening in England from 6480 participating general practices were randomly allocated to receive a GP-endorsed or the standard invitation letter. The primary outcome was the proportion of people adequately screened and its variation by quintile of Index of Multiple Deprivation. Results: We enrolled 265 434 individuals. Uptake was 58.2% in the intervention arm and 57.5% in the control arm. After adjusting for age, sex, hub and screening episode, GPE increased the overall odds of uptake (OR=1.07, 95% CI 1.04–1.10), but did not affect its socioeconomic gradient. We estimated that implementing GPE could result in up to 165 more people with high or intermediate risk colorectal adenomas and 61 cancers detected, and a small one-off cost to modify the standard invitation (£78 000). Conclusions: Although GPE did not improve its socioeconomic gradient, it offers a low-cost approach to enhancing overall screening uptake within the NHS BCSP.
DOI Link: 10.1038/bjc.2015.413
Rights: From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/
Notes: Additional co-authors: Stephen Halloran, Graham Handley, Richard F Logan, Sandra Rainbow, Steve Smith, Mary C Thomas, Wendy Atkin
Licence URL(s): http://creativecommons.org/licenses/by-nc-sa/4.0/

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