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Appears in Collections:Psychology Journal Articles
Peer Review Status: Refereed
Title: Assessing the Completeness of Reporting in Preclinical Oncolytic Virus Therapy Studies
Author(s): Fergusson, Dean A
Wesch, Neil L
Leung, Garvin J
MacNeil, Jenna L
Conic, Isidora
Presseau, Justin
Cobey, Kelly D
Diallo, Jean-Simon
Auer, Rebecca
Kimmelman, Jonathan
Kekre, Natasha
El-Sayes, Nader
Krishnan, Ramya
Keller, Brian A
Ilkow, Carolina
Lalu, Manoj M
Issue Date: 27-Sep-2019
Citation: Fergusson DA, Wesch NL, Leung GJ, MacNeil JL, Conic I, Presseau J, Cobey KD, Diallo J, Auer R, Kimmelman J, Kekre N, El-Sayes N, Krishnan R, Keller BA, Ilkow C & Lalu MM (2019) Assessing the Completeness of Reporting in Preclinical Oncolytic Virus Therapy Studies. Molecular Therapy - Oncolytics, 14, pp. 179-187.
Abstract: Irreproducibility of preclinical findings could be a significant barrier to the “bench-to-bedside” development of oncolytic viruses (OVs). A contributing factor is the incomplete and non-transparent reporting of study methodology and design. Using the NIH Principles and Guidelines for Reporting Preclinical Research, a core set of seven recommendations, we evaluated the completeness of reporting of preclinical OV studies. We also developed an evidence map identifying the current trends in OV research. A systematic search of MEDLINE and Embase identified all relevant articles published over an 18 month period. We screened 1,554 articles, and 236 met our a priori-defined inclusion criteria. Adenovirus (43%) was the most commonly used viral platform. Frequently investigated cancers included colorectal (14%), skin (12%), and breast (11%). Xenograft implantation (61%) in mice (96%) was the most common animal model. The use of preclinical reporting guidelines was listed in 0.4% of articles. Biological and technical replicates were completely reported in 1% of studies, statistics in 49%, randomization in 1%, blinding in 2%, sample size estimation in 0%, and inclusion/exclusion criteria in 0%. Overall, completeness of reporting in the preclinical OV therapy literature is poor. This may hinder efforts to interpret, replicate, and ultimately translate promising preclinical OV findings.
DOI Link: 10.1016/j.omto.2019.05.004
Rights: © 2019 The Author(s) This article has been published under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International license (CC BY-NC-ND -
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