Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/30063
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dc.contributor.authorO’Connor, Daryl Ben_UK
dc.contributor.authorBranley-Bell, Dawnen_UK
dc.contributor.authorGreen, Jessica Aen_UK
dc.contributor.authorFerguson, Eamonnen_UK
dc.contributor.authorO’Carroll, Ronan Een_UK
dc.contributor.authorO’Connor, Rory Cen_UK
dc.date.accessioned2019-09-11T00:00:55Z-
dc.date.available2019-09-11T00:00:55Z-
dc.date.issued2020en_UK
dc.identifier.urihttp://hdl.handle.net/1893/30063-
dc.description.abstractObjectives: Suicide is a leading cause of mortality worldwide. Dysregulated hypothalamic-pituitary-adrenal axis activity, as measured by cortisol levels, has been identified as one potential risk factor. Evidence has indicated that childhood trauma is associated with dysregulated cortisol reactivity to stress in adulthood. The current study investigated for the first time whether childhood trauma and daily stressors and emotions were associated with diurnal cortisol levels over a 7-day study in individuals vulnerable to suicide. Methods: 142 participants were categorized according to their suicidal history into three groups: suicide attempt, suicidal ideation or control group. Participants completed questionnaires before commencing a 7-day study. Cortisol samples were provided immediately upon waking, at 15 mins, 30 mins, 45 mins, 3 hours, 6 hours, 9 hours and 12 hours on 7 consecutive days. Measures of daily stressors, mood, defeat and entrapment were completed at the end of each day. Results: Participants in the suicide attempt and ideation groups released significantly lower cortisol upon awakening (CAR) and had a tendency towards flatter wake-peak to 12 hour (WP-12) cortisol slopes compared to controls. Childhood trauma was found to be associated with significantly lower CAR and a tendency towards flatter WP-12 cortisol slope. Childhood trauma also had an indirect effect on suicide vulnerability group membership via lower daily CAR levels. Lower CAR was associated with increased suicide ideation at 1-month but not 6-months. Daily stress and emotion measures were not associated with cortisol levels. Conclusions: This is the first 7-day daily diary investigation of naturally fluctuating cortisol levels in individuals vulnerable to suicide. The results indicate that dysregulated hypothalamic-pituitary-adrenal (HPA) axis activity is associated with suicidal ideation and behavior. Childhood trauma appears to be an important distal factor associated with HPA-axis dysregulation.en_UK
dc.language.isoenen_UK
dc.publisherAmerican Psychological Associationen_UK
dc.relationO’Connor DB, Branley-Bell D, Green JA, Ferguson E, O’Carroll RE & O’Connor RC (2020) Effects of Childhood Trauma, Daily Stress, and Emotions on Daily Cortisol Levels in Individuals Vulnerable to Suicide. Journal of Abnormal Psychology, 129 (1), pp. 92-107. https://doi.org/10.1037/abn0000482en_UK
dc.rights©American Psychological Association, 2019. This paper is not the copy of record and may not exactly replicate the authoritative document published in the APA journal. Please do not copy or cite without author's permission. The final article is available, upon publication, at: https://doi.org/10.1037/abn0000482en_UK
dc.subjectearly life adversityen_UK
dc.subjectstressen_UK
dc.subjectallostatic loaden_UK
dc.subjectcortisol reactivityen_UK
dc.subjectcortisol awakening responseen_UK
dc.titleEffects of Childhood Trauma, Daily Stress, and Emotions on Daily Cortisol Levels in Individuals Vulnerable to Suicideen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1037/abn0000482en_UK
dc.identifier.pmid31657598en_UK
dc.citation.jtitleJournal of Abnormal Psychologyen_UK
dc.citation.issn1939-1846en_UK
dc.citation.issn0021-843Xen_UK
dc.citation.volume129en_UK
dc.citation.issue1en_UK
dc.citation.spage92en_UK
dc.citation.epage107en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.citation.date28/10/2019en_UK
dc.contributor.affiliationUniversity of Leedsen_UK
dc.contributor.affiliationNewcastle Universityen_UK
dc.contributor.affiliationUniversity of Leedsen_UK
dc.contributor.affiliationUniversity of Nottinghamen_UK
dc.contributor.affiliationPsychologyen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.identifier.isiWOS:000504010400012en_UK
dc.identifier.scopusid2-s2.0-85074661641en_UK
dc.identifier.wtid1442629en_UK
dc.contributor.orcid0000-0002-5130-291Xen_UK
dc.date.accepted2019-09-09en_UK
dc.date.filedepositdate2019-09-10en_UK
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