Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/30004
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dc.contributor.authorElkhateeb, Waill Aen_UK
dc.contributor.authorDaba, Ghoson Men_UK
dc.contributor.authorSheir, Doniaen_UK
dc.contributor.authorEl-Dein, Asmaa Negmen_UK
dc.contributor.authorFayad, Waliden_UK
dc.contributor.authorElmahdy, Elmahdy Men_UK
dc.contributor.authorShaheen, Mohamed N Fen_UK
dc.contributor.authorThomas, Paul Wen_UK
dc.contributor.authorWen, Ting-Chien_UK
dc.date.accessioned2019-08-21T00:00:45Z-
dc.date.available2019-08-21T00:00:45Z-
dc.date.issued2019-06en_UK
dc.identifier.urihttp://hdl.handle.net/1893/30004-
dc.description.abstractBackground and objective Medicinal mushrooms are mines of various biologically active compounds. Therefore, chemical analysis and in-vitro evaluation of some biological activities of the Japanese originated mushroom Ganoderma spp. were conducted. Materials and methods Extraction of the fruiting bodies of Ganoderma spp. was accomplished using 80% methanol. This extract was investigated for its in-vitro cholesterol-lowering activity, anti-rotavirus effect, and anti-human colon cancer influence. Moreover, a gas chromatography–mass spectrometry analysis for this extract was performed. Results and conclusion The gas chromatography–mass spectrometry analysis resulted in the detection of 39 compounds, which were generally saturated and unsaturated fatty acids, and alkenes. The crude extract exhibited a promising in-vitro cholesterol-lowering activity (100±0%) after 96 h of incubation at room temperature. The same crude extract showed a moderate anti-rotavirus SA-11 strain effect with a therapeutic index of 9.3. Moreover, Ganoderma spp. extract displayed a strong activity toward HCT116 human colon carcinoma cell line, resulting in a cytotoxicity of 84.03±0.93% on HCT116 cell line monolayers. Ganoderma spp. crude extract represents a promising source of biologically active compounds that could by further investigations represent support and/or alternative to the currently used drugs.en_UK
dc.language.isoenen_UK
dc.publisherMedknow Publicationsen_UK
dc.relationElkhateeb WA, Daba GM, Sheir D, El-Dein AN, Fayad W, Elmahdy EM, Shaheen MNF, Thomas PW & Wen T (2019) GC-MS analysis and in-vitro hypocholesterolemic, anti-rotavirus, anti-human colon carcinoma activities of the crude extract of a Japanese Ganoderma spp. Egyptian Pharmaceutical Journal, 18 (2), pp. 102-110. https://doi.org/10.4103/epj.epj_50_18en_UK
dc.rightsThis is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License (http://creativecommons.org/licenses/by-nc-sa/4.0/), which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/4.0/en_UK
dc.subjectbiological activityen_UK
dc.subjectGanodermaen_UK
dc.subjectgas chromatography–mass spectrometryen_UK
dc.subjecthuman colon canceren_UK
dc.subjecthypocholesterolemic activityen_UK
dc.subjectrotavirusen_UK
dc.titleGC-MS analysis and in-vitro hypocholesterolemic, anti-rotavirus, anti-human colon carcinoma activities of the crude extract of a Japanese Ganoderma sppen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.4103/epj.epj_50_18en_UK
dc.citation.jtitleEgyptian Pharmaceutical Journalen_UK
dc.citation.issn2090-9853en_UK
dc.citation.issn1687-4315en_UK
dc.citation.volume18en_UK
dc.citation.issue2en_UK
dc.citation.spage102en_UK
dc.citation.epage110en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationEgyptian National Research Centreen_UK
dc.contributor.affiliationEgyptian National Research Centreen_UK
dc.contributor.affiliationEgyptian National Research Centreen_UK
dc.contributor.affiliationEgyptian National Research Centreen_UK
dc.contributor.affiliationEgyptian National Research Centreen_UK
dc.contributor.affiliationEgyptian National Research Centreen_UK
dc.contributor.affiliationEgyptian National Research Centreen_UK
dc.contributor.affiliationBiological and Environmental Sciencesen_UK
dc.contributor.affiliationGuizhou Universityen_UK
dc.identifier.isiWOS:000475624400003en_UK
dc.identifier.wtid1429832en_UK
dc.date.accepted2019-01-02en_UK
dcterms.dateAccepted2019-01-02en_UK
dc.date.filedepositdate2019-08-19en_UK
rioxxterms.apcnot chargeden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorElkhateeb, Waill A|en_UK
local.rioxx.authorDaba, Ghoson M|en_UK
local.rioxx.authorSheir, Donia|en_UK
local.rioxx.authorEl-Dein, Asmaa Negm|en_UK
local.rioxx.authorFayad, Walid|en_UK
local.rioxx.authorElmahdy, Elmahdy M|en_UK
local.rioxx.authorShaheen, Mohamed N F|en_UK
local.rioxx.authorThomas, Paul W|en_UK
local.rioxx.authorWen, Ting-Chi|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2019-08-19en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by-nc-sa/4.0/|2019-08-19|en_UK
local.rioxx.filenameEgyptPharmaceutJ182102-2456305_064923.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1687-4315en_UK
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