Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/29940
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dc.contributor.authorMartinsen, Anneloesen_UK
dc.contributor.authorTejera, Noemien_UK
dc.contributor.authorVauzour, Daviden_UK
dc.contributor.authorHarden, Glennen_UK
dc.contributor.authorDick, Jamesen_UK
dc.contributor.authorShinde, Sujataen_UK
dc.contributor.authorBarden, Anneen_UK
dc.contributor.authorMori, Trevor Aen_UK
dc.contributor.authorMinihane, Anne Marieen_UK
dc.date.accessioned2019-07-31T00:02:08Z-
dc.date.available2019-07-31T00:02:08Z-
dc.date.issued2019-09en_UK
dc.identifier.urihttp://hdl.handle.net/1893/29940-
dc.description.abstractAn apolipoprotein E (APOE) 4 genotype is the most important, common genetic determinant for Alzheimer disease (AD), and female APOE4 carriers present with an increased risk compared with males. The study quantified cortical and hippocampal fatty acid and phospholipid profiles along with select eicosapentaenoic acid (EPA)- and docosahexaenoic acid (DHA)-derived specialized proresolving mediators (SPMs) in 2-, 9-, and 18-mo-old APOE3 and APOE4 male and female mice. A 10% lower cortical DHA was evident in APOE4 females at 18 mo compared with 2 mo, with no significant decrease in APOE3 or APOE4 males. This decrease was associated with a reduction in DHA-phosphatidylethanolamine. Older APOE4 females had a 15% higher oleic acid content compared with young mice. Although no sex*APOE genotype interactions were observed for SPMs expressed as a ratio of their parent compound, higher cortical 18R/S-hydroxy-5Z,8Z,11Z,14Z,16E-EPA, resolvin D3, protectin D1, 10S,17S-dihydroxy-4Z,7Z,11E,13E,15Z,19Z-DHA (10S,17S-diHDHA), maresin 1, 17S-hydroxy-4Z,7Z,10Z,13Z,15E,19Z-DHA, and 14S-hydroxy-4Z,7Z,10Z,12E,16Z,19Z-DHA were evident in females, and lower cortical 17R-resolvin D1, 10S,17S-diHDHA, and 18-HEPE in APOE4. Our findings show a strong association between age, female sex, and an APOE4 genotype, with decreased cortical DHA and a number of SPMs, which together may contribute to the development of cognitive decline and AD pathology.—Martinsen, A., Tejera, N., Vauzour, D., Harden, G., Dick, J., Shinde, S., Barden, A., Mori, T. A., Minihane, A. M. Altered SPMs and age-associated decrease in brain DHA in APOE4 female mice.en_UK
dc.language.isoenen_UK
dc.publisherFederation of American Society of Experimental Biologyen_UK
dc.relationMartinsen A, Tejera N, Vauzour D, Harden G, Dick J, Shinde S, Barden A, Mori TA & Minihane AM (2019) Altered SPMs and age-associated decrease in brain DHA in APOE4 female mice. FASEB Journal, 33 (9), pp. 10315-10326. https://doi.org/10.1096/fj.201900423Ren_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_UK
dc.subjectAlzheimer diseaseen_UK
dc.subjectfatty acidsen_UK
dc.subjectspecialized proresolving mediatorsen_UK
dc.subjectneuroinflammationen_UK
dc.subjectcortexen_UK
dc.titleAltered SPMs and age-associated decrease in brain DHA in APOE4 female miceen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-31en_UK
dc.rights.embargoreason[Martinsen et al_final 2019.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.doi10.1096/fj.201900423Ren_UK
dc.identifier.pmid31251078en_UK
dc.citation.jtitleFASEB Journalen_UK
dc.citation.issn1530-6860en_UK
dc.citation.issn0892-6638en_UK
dc.citation.volume33en_UK
dc.citation.issue9en_UK
dc.citation.spage10315en_UK
dc.citation.epage10326en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderBiotechnology and Biological Sciences Research Councilen_UK
dc.author.emailj.r.dick@stir.ac.uken_UK
dc.citation.date28/06/2019en_UK
dc.contributor.affiliationUniversity of East Angliaen_UK
dc.contributor.affiliationUniversity of East Angliaen_UK
dc.contributor.affiliationUniversity of East Angliaen_UK
dc.contributor.affiliationUniversity of East Angliaen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationUniversity of Western Australiaen_UK
dc.contributor.affiliationUniversity of Western Australiaen_UK
dc.contributor.affiliationUniversity of Western Australiaen_UK
dc.contributor.affiliationUniversity of East Angliaen_UK
dc.identifier.isiWOS:000482214200048en_UK
dc.identifier.scopusid2-s2.0-85071785562en_UK
dc.identifier.wtid1406822en_UK
dc.date.accepted2019-05-21en_UK
dcterms.dateAccepted2019-05-21en_UK
dc.date.filedepositdate2019-07-30en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorMartinsen, Anneloes|en_UK
local.rioxx.authorTejera, Noemi|en_UK
local.rioxx.authorVauzour, David|en_UK
local.rioxx.authorHarden, Glenn|en_UK
local.rioxx.authorDick, James|en_UK
local.rioxx.authorShinde, Sujata|en_UK
local.rioxx.authorBarden, Anne|en_UK
local.rioxx.authorMori, Trevor A|en_UK
local.rioxx.authorMinihane, Anne Marie|en_UK
local.rioxx.projectProject ID unknown|Biotechnology and Biological Sciences Research Council|http://dx.doi.org/10.13039/501100000268en_UK
local.rioxx.freetoreaddate2269-05-29en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||en_UK
local.rioxx.filenameMartinsen et al_final 2019.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1530-6860en_UK
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