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dc.contributor.authorBrunton, Lucy Aen_UK
dc.contributor.authorDesbois, Andrew Pen_UK
dc.contributor.authorGarza, Mariaen_UK
dc.contributor.authorWieland, Barbaraen_UK
dc.contributor.authorMohan, Chadag Vishnumurthyen_UK
dc.contributor.authorHäsler, Barbaraen_UK
dc.contributor.authorTam, Clarence Cen_UK
dc.contributor.authorLe, Phuc Nguyen Thienen_UK
dc.contributor.authorPhuong, Nguyen Thanhen_UK
dc.contributor.authorVan, Phan Thien_UK
dc.contributor.authorNguyen-Viet, Hungen_UK
dc.contributor.authorEltholth, Mahmoud Men_UK
dc.contributor.authorPham, Dang Kimen_UK
dc.contributor.authorDuc, Phuc Phamen_UK
dc.contributor.authorAdams, Alexandraen_UK
dc.description.abstractAquaculture systems are highly complex, dynamic and interconnected systems influenced by environmental, biological, cultural, socio-economic and human behavioural factors. Intensification of aquaculture production is likely to drive indiscriminate use of antibiotics to treat or prevent disease and increase productivity, often to compensate for management and husbandry deficiencies. Surveillance or monitoring of antibiotic usage (ABU) and antibiotic resistance (ABR) is often lacking or absent. Consequently, there are knowledge gaps for the risk of ABR emergence and human exposure to ABR in these systems and the wider environment. The aim of this study was to use a systems-thinking approach to map two aquaculture systems in Vietnam – striped catfish and white-leg shrimp – to identify hotspots for emergence and selection of resistance, and human exposure to antibiotics and antibiotic-resistant bacteria. System mapping was conducted by stakeholders at an interdisciplinary workshop in Hanoi, Vietnam during January 2018, and the maps generated were refined until consensus. Thereafter, literature was reviewed to complement and cross-reference information and to validate the final maps. The maps and component interactions with the environment revealed the grow-out phase, where juveniles are cultured to harvest size, to be a key hotspot for emergence of ABR in both systems due to direct and indirect ABU, exposure to water contaminated with antibiotics and antibiotic-resistant bacteria, and duration of this stage. The pathways for human exposure to antibiotics and ABR were characterised as: occupational (on-farm and at different handling points along the value chain), through consumption (bacterial contamination and residues) and by environmental routes. By using systems thinking and mapping by stakeholders to identify hotspots we demonstrate the applicability of an integrated, interdisciplinary approach to characterising ABU in aquaculture. This work provides a foundation to quantify risks at different points, understand interactions between components, and identify stakeholders who can lead and implement change.en_UK
dc.publisherElsevier BVen_UK
dc.relationBrunton LA, Desbois AP, Garza M, Wieland B, Mohan CV, Häsler B, Tam CC, Le PNT, Phuong NT, Van PT, Nguyen-Viet H, Eltholth MM, Pham DK, Duc PP & Adams A (2019) Identifying hotspots for antibiotic resistance emergence and selection, and elucidating pathways to human exposure: Application of a systems-thinking approach to aquaculture systems. Science of The Total Environment, 687, pp. 1344-1356.
dc.rightsThis is an open access article distributed under the terms of the Creative Commons CC-BY license (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You are not required to obtain permission to reuse this article.en_UK
dc.subjectAntimicrobial resistance (AMR)en_UK
dc.subjectCá Traen_UK
dc.subjectMekong Deltaen_UK
dc.subjectOne Healthen_UK
dc.subjectPangasianodon hypophthalmusen_UK
dc.subjectPenaeus vannameien_UK
dc.titleIdentifying hotspots for antibiotic resistance emergence and selection, and elucidating pathways to human exposure: Application of a systems-thinking approach to aquaculture systemsen_UK
dc.typeJournal Articleen_UK
dc.citation.jtitleScience of the Total Environmenten_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderMedical Research Councilen_UK
dc.description.notesAdditional co-authors: Nguyen Tuong Linh, Karl M Rich, Ana L P Mateus, Md Ahasanul Hoque, Abdul Ahad, Mohammed Nurul Absar Khan, Javier Guitianen_UK
dc.contributor.affiliationRoyal Veterinary Collegeen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationRoyal Veterinary Collegeen_UK
dc.contributor.affiliationInternational Livestock Research Instituteen_UK
dc.contributor.affiliationRoyal Veterinary Collegeen_UK
dc.contributor.affiliationLondon School of Hygiene and Tropical Medicineen_UK
dc.contributor.affiliationVietnam National University Ho Chi Minh City International Universityen_UK
dc.contributor.affiliationCan Tho Universityen_UK
dc.contributor.affiliationResearch Institute for Aquaculture, Vietnamen_UK
dc.contributor.affiliationInternational Livestock Research Instituteen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationVietnam National University, Hanoien_UK
dc.contributor.affiliationHanoi University of Public Healthen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorBrunton, Lucy A|en_UK
local.rioxx.authorDesbois, Andrew P|0000-0001-6052-8761en_UK
local.rioxx.authorGarza, Maria|en_UK
local.rioxx.authorWieland, Barbara|en_UK
local.rioxx.authorMohan, Chadag Vishnumurthy|en_UK
local.rioxx.authorHäsler, Barbara|en_UK
local.rioxx.authorTam, Clarence C|en_UK
local.rioxx.authorLe, Phuc Nguyen Thien|en_UK
local.rioxx.authorPhuong, Nguyen Thanh|en_UK
local.rioxx.authorVan, Phan Thi|en_UK
local.rioxx.authorNguyen-Viet, Hung|en_UK
local.rioxx.authorEltholth, Mahmoud M|0000-0001-8635-8879en_UK
local.rioxx.authorPham, Dang Kim|en_UK
local.rioxx.authorDuc, Phuc Pham|en_UK
local.rioxx.authorAdams, Alexandra|en_UK
local.rioxx.projectProject ID unknown|Medical Research Council|
Appears in Collections:Aquaculture Journal Articles

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