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dc.contributor.authorLawrie, Stephen Men_UK
dc.contributor.authorMacHale, Siobhan Men_UK
dc.contributor.authorCavanagh, Jonathan T Oen_UK
dc.contributor.authorO'Carroll, Ronanen_UK
dc.contributor.authorGoodwin, Guy Men_UK
dc.description.abstractBackground. Chronic fatigue syndrome (CFS) and major depressive disorder (MDD) share many symptoms and aetiological factors but may have different neurobiological underpinnings. We wished to determine the profile of the biological variables disturbed in CFS and MDD, and identify any critical factors that differentiate the disorders. Methods. Thirty patients with CFS, 20 with MDD and 15 healthy controls – matched group-wise for age and sex – were recruited. Subjects were given a detailed battery of motor and cognitive tests, including measures of psychomotor speed, memory and maximal voluntary muscle contraction in both the morning and evening that were balanced to avoid order effects. Results. CFS patients generally performed worse on cognitive tests than healthy controls, but better than patients with MDD. Both patient groups had markedly impaired motor function compared with healthy controls. MDD subjects showed a significantly greater diurnal improvement in maximal voluntary contraction than healthy controls. Conclusions. Patients with CFS and MDD show similarly substantial motor impairment, but cognitive deficits are generally more marked in MDD. Diurnal changes in some functions in MDD may differentiate the disorder from CFS.en_UK
dc.publisherCambridge University Pressen_UK
dc.relationLawrie SM, MacHale SM, Cavanagh JTO, O'Carroll R & Goodwin GM (2000) The difference in patterns of motor and cognitive function in chronic fatigue syndrome and severe depressive illness, Psychological Medicine, 30 (2), pp. 433-442.
dc.rightsPublished in Psychological Medicine. Copyright: Cambridge University Press.en_UK
dc.subjectChronic fatigue syndrome Symptomsen_UK
dc.subjectDepressive Disorder Symptomsen_UK
dc.titleThe difference in patterns of motor and cognitive function in chronic fatigue syndrome and severe depressive illnessen_UK
dc.typeJournal Articleen_UK
dc.citation.jtitlePsychological Medicineen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Oxforden_UK
Appears in Collections:Psychology Journal Articles

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