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dc.contributor.authorZheng, Xiaozhongen_UK
dc.contributor.authorTorstensen, Bente Een_UK
dc.contributor.authorTocher, Douglas Ren_UK
dc.contributor.authorDick, James Ren_UK
dc.contributor.authorHenderson, R Jamesen_UK
dc.contributor.authorBell, J Gordonen_UK
dc.description.abstractHighly unsaturated fatty acid (HUFA) synthesis in Atlantic salmon (Salmo salar) was known to be influenced by both nutritional and environmental factors. Here we aimed to test the hypothesis that both these effectors involved similar molecular mechanisms. Thus, HUFA biosynthetic activity and the expression of fatty acyl desaturase and elongase genes were determined at various points during an entire two year production cycle in salmon fed diets containing either 100% fish oil or diets in which a high proportion (75% and 100%) of fish oil was replaced by C18 polyunsaturated fatty acid-rich vegetable oil. The results showed that HUFA biosynthesis in Atlantic salmon varied during the growth cycle with peak activity around seawater transfer and subsequent low activities in seawater. Consistent with this, gene expression of Δ6 desaturase, the rate-limiting step in the HUFA biosynthetic pathway, was highest around the point of seawater transfer and lowest during the seawater phase. In addition, the expression of both Δ6 and Δ5 desaturase genes was generally higher in fish fed the vegetable oil-substituted diets compared to fish fed fish oil, particularly in the seawater phase. Again, generally consistent with this, the activity of the HUFA biosynthetic pathway was invariably higher in fish fed diets in which fish oil was substituted by vegetable oil compared to fish fed only fish oil. In conclusion, these studies showed that both nutritional and environmental modulation of HUFA biosynthesis in Atlantic salmon involved regulation of fatty acid desaturase gene expression.en_UK
dc.relationZheng X, Torstensen BE, Tocher DR, Dick JR, Henderson RJ & Bell JG (2005) Environmental and dietary influences on highly unsaturated fatty acid biosynthesis and expression of fatty acyl desaturase and elongase genes in liver of Atlantic salmon (Salmo salar). Biochimica et Biophysica Acta (BBA)- Molecular and Cell Biology of Lipids, 1734 (1), pp. 13-24.;
dc.rightsPublished in Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids by Elsevier. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, Volume 1734, Issue 1, May 2005, pp. 13 - 24.; This is the peer reviewed version of this article.; NOTICE: this is the author’s version of a work that was accepted for publication in Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, VOL 1734, ISSUE 1, (May 2005). DOI 10.1016/j.bbalip.2005.01.006.en_UK
dc.subjectAtlantic salmonen_UK
dc.subjectSalmo salaren_UK
dc.subjectfish oilen_UK
dc.subjectvegetable oilen_UK
dc.subjectpolyunsaturated fatty aciden_UK
dc.subjectGene expressionen_UK
dc.subjectEnzyme activityen_UK
dc.subjectEnvironmental regulationen_UK
dc.subjectNutritional regulationen_UK
dc.subjectFishes Nutrition Requirementsen_UK
dc.subjectFishes Feeding and feedsen_UK
dc.subjectFishes Nutritionen_UK
dc.titleEnvironmental and dietary influences on highly unsaturated fatty acid biosynthesis and expression of fatty acyl desaturase and elongase genes in liver of Atlantic salmon (Salmo salar)en_UK
dc.typeJournal Articleen_UK
dc.citation.jtitleBiochimica et Biophysica Acta Molecular and Cell Biology of Lipidsen_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationNational Institute of Nutrition and Seafood Research (NIFES)en_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationUniversity of Stirlingen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorZheng, Xiaozhong|en_UK
local.rioxx.authorTorstensen, Bente E|en_UK
local.rioxx.authorTocher, Douglas R|0000-0002-8603-9410en_UK
local.rioxx.authorDick, James R|en_UK
local.rioxx.authorHenderson, R James|en_UK
local.rioxx.authorBell, J Gordon|en_UK
local.rioxx.projectInternal Project|University of Stirling|
local.rioxx.filenameZhengetal final.pdfen_UK
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