Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/2917
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dc.contributor.authorJordal, Ann-Elise O-
dc.contributor.authorTorstensen, Bente E-
dc.contributor.authorTsoi, Stephen-
dc.contributor.authorTocher, Douglas R-
dc.contributor.authorLall, Santosh P-
dc.contributor.authorDouglas, Susan E-
dc.date.accessioned2012-09-03T12:20:48Z-
dc.date.issued2005-10-
dc.identifier.urihttp://hdl.handle.net/1893/2917-
dc.description.abstractSupplies of marine fish oils (FO ) are limited, and sustainable production in aquaculture dictates that alternatives, such as vegetable oils, must be found that do not compromise fish health and product quality. Nutrigenomics is anticipated to provide an increased understanding of how nutrition influences metabolic pathways and homeostatic control, and may be used to measure and validate subtle changes in organ-specific, metabolic gene expression signatures. We have compared two groups of Atlantic salmon fed diets containing 100% FO or 75% rapeseed oil (RO)/25% FO for 42 weeks. A small-scale cDNA microarray was constructed to screen for changes in expression of lipid metabolism genes in the liver resulting from this partial substitution of RO for FO. Fatty acid desaturase gene expression was significantly increased in fish fed 75% RO compared to fish fed the control diet; this was confirmed by quantitative Real Time PCR analysis (Q-PCR). In addition, several genes, among these mitochondrial proteins, peroxisome proliferator activated receptor-γ (PPARγ) as well as other transcription factors, co-activators and signal transducers, showed significant differential regulation. This partially validated microarray may be used for further gene expression profiling using other dietary comparisonen_UK
dc.language.isoen-
dc.publisherAmerican Society for Nutritional Sciences-
dc.relationJordal AO, Torstensen BE, Tsoi S, Tocher DR, Lall SP & Douglas SE (2005) Dietary rapeseed oil affects the expression of genes involved in hepatic lipid metabolism in Atlantic salmon (Salmo salar L.), Journal of Nutrition, 135 (10), pp. 2355-2361.-
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author; you can only request a copy if you wish to use this work for your own research or private study.-
dc.subjectAtlantic salmonen_UK
dc.subjectSalmo salaren_UK
dc.subjectfish olen_UK
dc.subjectvegetable oilen_UK
dc.subjectgene expressionen_UK
dc.subjectmicroarrayen_UK
dc.subjectQPCRen_UK
dc.subjectLipid metabolismen_UK
dc.subject.lcshAtlantic salmon-
dc.subject.lcshFishes Feeding and feeds-
dc.subject.lcshFishes Nutrition-
dc.subject.lcshDietary supplements-
dc.subject.lcshFishes Quality-
dc.titleDietary rapeseed oil affects the expression of genes involved in hepatic lipid metabolism in Atlantic salmon (Salmo salar L.)en_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-31T00:00:00Z-
dc.rights.embargoreasonThe publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.-
dc.citation.jtitleJournal of Nutrition-
dc.citation.issn0022-3166-
dc.citation.volume135-
dc.citation.issue10-
dc.citation.spage2355-
dc.citation.epage2361-
dc.citation.publicationstatusPublished-
dc.citation.peerreviewedRefereed-
dc.type.statusPost-print (author final draft post-refereeing)-
dc.identifier.urlhttp://jn.nutrition.org/content/135/10/2355.abstract-
dc.author.emaildrt1@stir.ac.uk-
dc.citation.date10/2005-
dc.contributor.affiliationNational Institute of Nutrition and Seafood Research (NIFES)-
dc.contributor.affiliationNational Institute of Nutrition and Seafood Research (NIFES)-
dc.contributor.affiliationNational Institute of Nutrition and Seafood Research (NIFES)-
dc.contributor.affiliationAquaculture-
dc.contributor.affiliationNational Institute of Nutrition and Seafood Research (NIFES)-
dc.contributor.affiliationNational Institute of Nutrition and Seafood Research (NIFES)-
dc.rights.embargoterms2999-12-31-
dc.rights.embargoliftdate2999-12-31-
Appears in Collections:Aquaculture Journal Articles

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