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Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/28654
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dc.contributor.authorWoldemariam, Nardos Tesfayeen_UK
dc.contributor.authorAgafonov, Olegen_UK
dc.contributor.authorHoyheim, Bjørnen_UK
dc.contributor.authorHouston, Ross Den_UK
dc.contributor.authorTaggart, John Ben_UK
dc.contributor.authorAndreassen, Runeen_UK
dc.date.accessioned2019-01-30T15:40:05Z-
dc.date.available2019-01-30T15:40:05Z-
dc.date.issued2019-01-11en_UK
dc.identifier.other42en_UK
dc.identifier.urihttp://hdl.handle.net/1893/28654-
dc.description.abstractMicroRNAs (miRNAs) are important post-transcriptional gene expression regulators. Here, 448 different miRNA genes, including 17 novel miRNAs, encoding for 589 mature Atlantic salmon miRNAs were identified after sequencing 111 samples (fry, pathogen challenged fry, various developmental and adult tissues). This increased the reference miRNAome with almost one hundred genes. Prior to isomiR characterization (mature miRNA variants), the proportion of erroneous sequence variants (ESVs) arising in the analysis pipeline was assessed. The ESVs were biased towards 5’ and 3’ end of reads in unexpectedly high proportions indicating that measurements of ESVs rather than Phred score should be used to avoid misinterpreting ESVs as isomiRs. Forty-three isomiRs were subsequently discovered. The biological effect of the isomiRs measured as increases in target diversity was small (en_UK
dc.language.isoenen_UK
dc.publisherMDPIen_UK
dc.relationWoldemariam NT, Agafonov O, Hoyheim B, Houston RD, Taggart JB & Andreassen R (2019) Expanding the miRNA Repertoire in Atlantic Salmon; Discovery of IsomiRs and miRNAs Highly Expressed in Different Tissues and Developmental Stages. Cells, 8 (1), Art. No.: 42. https://doi.org/10.3390/cells8010042en_UK
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.subjectTeleosteien_UK
dc.subjectembryogenesisen_UK
dc.subjecttissue-enriched miRNAsen_UK
dc.subjectpost-transcriptional gene regulationen_UK
dc.titleExpanding the miRNA Repertoire in Atlantic Salmon; Discovery of IsomiRs and miRNAs Highly Expressed in Different Tissues and Developmental Stagesen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.3390/cells8010042en_UK
dc.identifier.pmid30641951en_UK
dc.citation.jtitleCellsen_UK
dc.citation.issn2073-4409en_UK
dc.citation.volume8en_UK
dc.citation.issue1en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderNorwegian Research Councilen_UK
dc.citation.date11/01/2019en_UK
dc.contributor.affiliationOslo Metropolitan Universityen_UK
dc.contributor.affiliationUniversity of Osloen_UK
dc.contributor.affiliationNorwegian University of Life Sciencesen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationOslo Metropolitan Universityen_UK
dc.identifier.isiWOS:000459742400042en_UK
dc.identifier.wtid1101111en_UK
dc.contributor.orcid0000-0002-3843-9663en_UK
dc.date.accepted2018-12-18en_UK
dcterms.dateAccepted2018-12-18en_UK
dc.date.filedepositdate2019-01-30en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorWoldemariam, Nardos Tesfaye|en_UK
local.rioxx.authorAgafonov, Oleg|en_UK
local.rioxx.authorHoyheim, Bjørn|en_UK
local.rioxx.authorHouston, Ross D|en_UK
local.rioxx.authorTaggart, John B|0000-0002-3843-9663en_UK
local.rioxx.authorAndreassen, Rune|en_UK
local.rioxx.projectProject ID unknown|Norwegian Research Council|en_UK
local.rioxx.freetoreaddate2019-01-30en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by/4.0/|2019-01-30|en_UK
local.rioxx.filenamecells-08-00042.pdfen_UK
local.rioxx.filecount1en_UK
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