Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/28450
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dc.contributor.authorGharbi, Karimen_UK
dc.contributor.authorMatthews, Louiseen_UK
dc.contributor.authorBron, Jamesen_UK
dc.contributor.authorRoberts, Ronen_UK
dc.contributor.authorTinch, Alanen_UK
dc.contributor.authorStear, Michaelen_UK
dc.date.accessioned2018-12-22T01:05:30Z-
dc.date.available2018-12-22T01:05:30Z-
dc.date.issued2015-09-30en_UK
dc.identifier.other20150574en_UK
dc.identifier.urihttp://hdl.handle.net/1893/28450-
dc.description.abstractSea lice threaten the welfare of farmed Atlantic salmon and the sustainability of fish farming across the world. Chemical treatments are the major method of control but drug resistance means that alternatives are urgently needed. Selective breeding can be a cheap and effective alternative. Here, we combine experimental trials and diagnostics to provide a practical protocol for quantifying resistance to sea lice. We then combined quantitative genetics with epidemiological modelling to make the first prediction of the response to selection, quantified in terms of reduced need for chemical treatments. We infected over 1400 young fish with Lepeophtheirus salmonis, the most important species in the Northern Hemisphere. Mechanisms of resistance were expressed early in infection. Consequently, the number of lice per fish and the ranking of families were very similar at 7 and 17 days post infection, providing a stable window for assessing susceptibility to infection. The heritability of lice numbers within this time window was moderately high at 0.3, confirming that selective breeding is viable. We combined an epidemiological model of sea lice infection and control on a salmon farm with genetic variation in susceptibility among individuals. We simulated 10 generations of selective breeding and examined the frequency of treatments needed to control infection. Our model predicted that substantially fewer chemical treatments are needed to control lice outbreaks in selected populations and chemical treatment could be unnecessary after 10 generations of selection. Selective breeding for sea lice resistance should reduce the impact of sea lice on fish health and thus substantially improve the sustainability of Atlantic salmon production.en_UK
dc.language.isoenen_UK
dc.publisherRoyal Society, Theen_UK
dc.relationGharbi K, Matthews L, Bron J, Roberts R, Tinch A & Stear M (2015) The control of sea lice in Atlantic salmon by selective breeding. Interface, 12 (110), Art. No.: 20150574. https://doi.org/10.1098/rsif.2015.0574en_UK
dc.rightsCopyright 2015 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.subjectselective breedingen_UK
dc.subjectepidemiological modellingen_UK
dc.subjectsustainable agricultureen_UK
dc.subjectsea liceen_UK
dc.subjectLepeophtheirus salmonisen_UK
dc.subjectAtlantic salmonen_UK
dc.titleThe control of sea lice in Atlantic salmon by selective breedingen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1098/rsif.2015.0574en_UK
dc.identifier.pmid26289656en_UK
dc.citation.jtitleInterfaceen_UK
dc.citation.issn1742-5662en_UK
dc.citation.volume12en_UK
dc.citation.issue110en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderScottish Governmenten_UK
dc.citation.date06/09/2015en_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationLandcatch Natural Selection Ltden_UK
dc.contributor.affiliationLandcatch Natural Selection Ltden_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.identifier.isiWOS: WOS:000363224700018en_UK
dc.identifier.scopusid2-s2.0-84942028649en_UK
dc.identifier.wtid1078834en_UK
dc.contributor.orcid0000-0003-3544-0519en_UK
dc.date.accepted2015-07-28en_UK
dcterms.dateAccepted2015-07-28en_UK
dc.date.filedepositdate2018-12-20en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorGharbi, Karim|en_UK
local.rioxx.authorMatthews, Louise|en_UK
local.rioxx.authorBron, James|0000-0003-3544-0519en_UK
local.rioxx.authorRoberts, Ron|en_UK
local.rioxx.authorTinch, Alan|en_UK
local.rioxx.authorStear, Michael|en_UK
local.rioxx.projectProject ID unknown|Scottish Government|http://dx.doi.org/10.13039/100012095en_UK
local.rioxx.freetoreaddate2018-12-20en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by/4.0/|2018-12-20|en_UK
local.rioxx.filenameA6_The control of sea lice.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1742-5662en_UK
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