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dc.contributor.authorO'Carroll, Ronanen_UK
dc.contributor.authorDrysdale, Emma Een_UK
dc.contributor.authorCahill, Larryen_UK
dc.contributor.authorShajahan, Polashen_UK
dc.contributor.authorEbmeier, Klaus Pen_UK
dc.description.abstractBackground. It is clearly established that emotional events tend to be remembered particularly vividly. The neurobiological substrates of this phenomenon are poorly understood. Recently, the noradrenergic system has been implicated in that beta blockade has been shown to reduce significantly the delayed recall of emotional material with matched neutral material being unaffected. Methods. In the present study, 36 healthy young adults were randomly allocated to receive either yohimbine, which stimulates central noradrenergic activity, metoprolol which blocks noradrenergic activity, or matched placebo. The three groups were well matched. All capsules were taken orally, prior to viewing a narrated 11 slide show described a boy being involved in an accident. Results. Yohimbine significantly elevated, and metoprolol reduced mean heart rate during the slide show relative to placebo, thus confirming the efficacy of the pharmacological manipulation. One week later, in a ‘surprise’ test, memory for the slide show was tested. As predicted, yohimbine-treated subjects recalled significantly more and metoprolol subjects fewer slides relative to placebo. This result was confirmed via analysis of multiple-choice recognition memory scores. Conclusions. We conclude that stimulation of the noradrenergic system results in the enhancement and blockade in a reduction of recall and recognition of emotional material in man.en_UK
dc.publisherCambridge University Pressen_UK
dc.relationO'Carroll R, Drysdale EE, Cahill L, Shajahan P & Ebmeier KP (1999) Stimulation of the noradrenergic system enhances and blockade reduces memory for emotional material in man, Psychological Medicine, 29 (5), pp. 1083-1088.
dc.rightsPublished in: Psychological medicine. Copyright: Cambridge University Pressen_UK
dc.subjectMemory Emotionsen_UK
dc.subjectMemory Case studiesen_UK
dc.subjectMemory Effect of drugs onen_UK
dc.titleStimulation of the noradrenergic system enhances and blockade reduces memory for emotional material in manen_UK
dc.typeJournal Articleen_UK
dc.citation.jtitlePsychological Medicineen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationUniversity of Stirlingen_UK
dc.contributor.affiliationUniversity of Californiaen_UK
dc.contributor.affiliationUniversity of Californiaen_UK
dc.contributor.affiliationRoyal Edinburgh Hospital (NHS Lothian)en_UK
Appears in Collections:Psychology Journal Articles

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