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dc.contributor.authorBell, J Gordonen_UK
dc.contributor.authorStrachan, Fionaen_UK
dc.contributor.authorGood, Joanne Een_UK
dc.contributor.authorTocher, Douglas Ren_UK
dc.description.abstractEchium oil (EO) is a vegetable oil in which percentages of stearidonic acid (STA,18:4n-3) often exceed those of its n-6 series equivalent γ-linolenic acid (GLA, 18:3n-6). STA is elongated to 20:4n-3 in fish cell cultures, suggesting that EO could be included in diets for marine fish to increase tissue 20:4n-3 and 20:3n-6 and, thereby, modulate eicosanoid metabolism. Thus, the present study aimed to test the hypotheses that dietary EO would increase tissue 20:4n-3 and 20:3n-6 and modulate immune function and eicosanoid production in juvenile Atlantic cod (Gadus morhua L.) fed a diet where fish oil (FO) was replaced by EO. Duplicate groups of juvenile cod (initial weight ca. 4g) were fed for 18 weeks on fish meal based diets (55% protein and 16% lipid) that differed in oil source (FO or EO). There were no significant differences in growth and feed efficiency, hepato-somatic index, percentages of liver and flesh lipids and lipid class compositions for cod fed FO and EO. Percentages of 18:4n-3, 18:3n-6 and 20:3n-6 in the total lipids of flesh and liver were higher, and percentages of 20:5n-3 and 20:4n-6 were both lower in fish fed EO than in those given FO. In flesh, the increased 18:3n-6 and 18:4n-3 were primarily located in phosphatidylcholine and, to a lesser extent, phosphatidylethanolamine, whereas 20:3n-6 concentration was highest in phosphatidylinositol. Desaturation of 18:3n-3 (to tetraene products) and 20:5n-3 to 22:6n-3 in hepatocytes was very low but was increased by dietary EO. EO significantly decreased the production of prostaglandin F from gill cells stimulated with calcium ionophore A23187, and reduced head kidney macrophage activity, but had no effect on serum lysozyme activity or basic haematology. In conclusion, dietary EO may have beneficial effects on some immune parameters including eicosanoid metabolism in marine fish although this may be primarily due to decreased 20:4n-6 rather than increasing tissue levels of 20:3n-6 or 20:4n-3.en_UK
dc.relationBell JG, Strachan F, Good JE & Tocher DR (2006) Effect of dietary echium oil on growth, fatty acid composition and metabolism, gill prostaglandin production and macrophage activity in Atlantic cod (Gadus morhua L.). Aquaculture Research, 37 (6), pp. 606-617.
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author; you can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.subjectAtlantic coden_UK
dc.subjectGadus morhuaen_UK
dc.subjectEchium oilen_UK
dc.subjectFish oilen_UK
dc.subjectVegetable oilen_UK
dc.subjectLipid metabolismen_UK
dc.subjectAtlantic coden_UK
dc.subjectLipoproteins Fishen_UK
dc.subjectFishes Qualityen_UK
dc.subjectFish Feeding and feedsen_UK
dc.titleEffect of dietary echium oil on growth, fatty acid composition and metabolism, gill prostaglandin production and macrophage activity in Atlantic cod (Gadus morhua L.)en_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreason[Echium-Cod.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.citation.jtitleAquaculture Researchen_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationUniversity of Stirlingen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorBell, J Gordon|en_UK
local.rioxx.authorStrachan, Fiona|en_UK
local.rioxx.authorGood, Joanne E|en_UK
local.rioxx.authorTocher, Douglas R|0000-0002-8603-9410en_UK
local.rioxx.projectInternal Project|University of Stirling|
Appears in Collections:Aquaculture Journal Articles

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