Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/27884
Appears in Collections:Psychology Journal Articles
Peer Review Status: Refereed
Title: Alcohol and the Developing Brain: Why Neurons Die and How Survivors Change
Author(s): Granato, Alberto
Dering, Benjamin
Keywords: fetal alcohol
GABA
ethanol
cerebral cortex
pyramidal neurons
apoptosis
Issue Date: 30-Sep-2018
Citation: Granato A & Dering B (2018) Alcohol and the Developing Brain: Why Neurons Die and How Survivors Change. International Journal of Molecular Sciences, 19 (10), Art. No.: 2992. https://doi.org/10.3390/ijms19102992.
Abstract: The consequences of alcohol drinking during pregnancy are dramatic and usually referred to as fetal alcohol spectrum disorders (FASD). This condition is one of the main causes of intellectual disability in Western countries. The immature fetal brain exposed to ethanol undergoes massive neuron death. However, the same mechanisms leading to cell death can also be responsible for changes of developmental plasticity. As a consequence of such a maladaptive plasticity, the functional damage to central nervous system structures is amplified and leads to permanent sequelae. Here we review the literature dealing with experimental FASD, focusing on the alterations of the cerebral cortex. We propose that the reciprocal interaction between cell death and maladaptive plasticity represents the main pathogenetic mechanism of the alcohol-induced damage to the developing brain.
DOI Link: 10.3390/ijms19102992
Rights: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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