Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/27794
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dc.contributor.authorUlrich, Kristinaen_UK
dc.contributor.authorWehner, Stefanieen_UK
dc.contributor.authorBekaert, Michaëlen_UK
dc.contributor.authorPaola, Nicholas Dien_UK
dc.contributor.authorDilcher, Meiken_UK
dc.contributor.authorMuir, Katherine Fionaen_UK
dc.contributor.authorTaggart, John Ben_UK
dc.contributor.authorMatejusova, Ivetaen_UK
dc.contributor.authorWeidmann, Manfreden_UK
dc.date.accessioned2018-09-13T14:37:44Z-
dc.date.available2018-09-13T14:37:44Z-
dc.date.issued2018-12-01en_UK
dc.identifier.urihttp://hdl.handle.net/1893/27794-
dc.description.abstractIn order to obtain an insight into genomic changes and associated evolution and adaptation of Infectious Pancreatic Necrosis Virus (IPNV) the complete coding genomes of 57 IPNV isolates collected from Scottish aquafarms from 1982-2014 were sequenced and analysed. Phylogenetic analysis of the sequenced IPNV strains showed separate clustering of genogroups I, II, III and V. IPNV isolates with genetic reassortment of segment A/B of genogroup III/II were determined. About 59% of the IPNV isolates belonged to the persistent type and 32% to the low virulent type and only one highly pathogenic strain0 (1.79%) was identified. Codon adaptation index calculations indicated that the IPNV major capsid protein VP2 has adapted to its salmonid host. Underrepresentation of CpG dinucleotides in the IPNV genome to minimise detection by the innate immunity receptors, and observed positive selection in the virulence determination sites of VP2 embedded in the variable region of the main antigenic region, suggest an immune escape mechanism driving virulence evolution. The prevalence of mostly persistent genotypes together with the assumption of adaptation and immune escape indicates that IPNV is evolving with the host.en_UK
dc.language.isoenen_UK
dc.publisherMicrobiology Societyen_UK
dc.relationUlrich K, Wehner S, Bekaert M, Paola ND, Dilcher M, Muir KF, Taggart JB, Matejusova I & Weidmann M (2018) Molecular epidemiological study on Infectious Pancreatic Necrosis Virus isolates from aquafarms in Scotland over three decades. Journal of General Virology, 99 (12), pp. 1567-1581. https://doi.org/10.1099/jgv.0.001155.en_UK
dc.rightsPublisher allows this work to be made available in this repository. Published in Journal of General Virology by Microbiology Society with the following policy: We permit all forms of non-commercial reuse of pre-prints and post-prints, including non-commercial text and data mining. This includes use for the purpose of research, teaching or other related activity, but not use for the purposes of monetary reward by means of sale, resale, loan, transfer, hire or other form of exploitation. The published version is available at: https://doi.org/10.1099/jgv.0.001155en_UK
dc.subjectInfectious Pancreatic Necrosis Virusen_UK
dc.subjectIPNVen_UK
dc.subjectSalmonen_UK
dc.subjectevolutionen_UK
dc.subjectCodon adaptationen_UK
dc.subjectphylogenyen_UK
dc.subjectselectionen_UK
dc.subjectvaccineen_UK
dc.subjectadaptationen_UK
dc.subjectAquacultureen_UK
dc.titleMolecular epidemiological study on Infectious Pancreatic Necrosis Virus isolates from aquafarms in Scotland over three decadesen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1099/jgv.0.001155en_UK
dc.identifier.pmid30358526en_UK
dc.citation.jtitleJournal of General Virologyen_UK
dc.citation.issn1465-2099en_UK
dc.citation.issn0022-1317en_UK
dc.citation.volume99en_UK
dc.citation.issue12en_UK
dc.citation.spage1567en_UK
dc.citation.epage1581en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.contributor.funderMarine Alliance for Science & Technology Scotlanden_UK
dc.citation.date25/10/2018en_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationMax Planck Institute of Psychiatryen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationUniversity of Sao Pauloen_UK
dc.contributor.affiliationCanterbury Health Laboratoriesen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationScottish Government - Enterprise, Environment & Digital - Marine Scotlanden_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.identifier.isiWOS:000451921000005en_UK
dc.identifier.scopusid2-s2.0-85059699071en_UK
dc.identifier.wtid997358en_UK
dc.contributor.orcid0000-0002-1206-7654en_UK
dc.contributor.orcid0000-0002-3843-9663en_UK
dc.contributor.orcid0000-0002-7063-7491en_UK
dc.date.accepted2018-09-07en_UK
dc.date.firstcompliantdepositdate2018-09-13en_UK
dc.description.refREF Compliant by Deposit in Stirling's Repositoryen_UK
Appears in Collections:Aquaculture Journal Articles

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