Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/27649
Full metadata record
DC FieldValueLanguage
dc.contributor.authorWardlaw, Joanna Men_UK
dc.contributor.authorBastin, Mark Een_UK
dc.contributor.authorValdés Hernández, Maria Cen_UK
dc.contributor.authorManiega, Susana Muñozen_UK
dc.contributor.authorRoyle, Natalie Aen_UK
dc.contributor.authorMorris, Zoeen_UK
dc.contributor.authorClayden, Jonathan Den_UK
dc.contributor.authorSandeman, Elaine Men_UK
dc.contributor.authorEadie, Elizabethen_UK
dc.contributor.authorMurray, Catherineen_UK
dc.contributor.authorStarr, John Men_UK
dc.contributor.authorDeary, Ian Jen_UK
dc.date.accessioned2018-08-18T00:01:24Z-
dc.date.available2018-08-18T00:01:24Z-
dc.date.issued2011-12-01en_UK
dc.identifier.urihttp://hdl.handle.net/1893/27649-
dc.description.abstractRationale As the population of the world ages, age-related cognitive decline is becoming an ever-increasing problem. However, the changes in brain structure that accompany normal aging, and the role they play in cognitive decline, remain to be fully elucidated. Aims This study aims to characterize changes in brain structure in old age, and to investigate relationships between brain aging and cognitive decline using the Lothian Birth Cohort 1936. Here, we report the rationale, design and methodology of the brain and neurovascular imaging protocol developed to study this cohort. Design An observational, longitudinal study of the Lothian Birth Cohort 1936, which comprises 1091 relatively healthy individuals now in their 70s and living in the Edinburgh area. They are surviving participants of the Scottish Mental Survey 1947, which involved a test of general intelligence taken at age 11 years. At age 70 years, the Lothian Birth Cohort 1936 undertook detailed cognitive, medical and genetic testing, and provided social, family, nutritional, quality of life and physical activity information. At mean age 73 years they underwent detailed brain MRI and neurovascular ultrasound imaging, repeat cognitive and other testing. The MRI protocol is designed to provide qualitative and quantitative measures of gray and white matter atrophy, severity and location of white matter lesions, enlarged perivascular spaces, brain mineral deposits, microbleeds and integrity of major white matter tracts. The neurovascular ultrasound imaging provides velocity, stenosis and intima–media thickness measurements of the carotid and vertebral arteries. Study This valuable imaging dataset will be used to determine which changes in brain structural parameters have the largest effects on cognitive aging. Analysis will include multimodal image analysis and multivariate techniques, such as factor analysis and structural equation modelling. Especially valuable is the ability within this sample to examine the influence that early life intelligence has on brain structural parameters in old age, and the role of genetic, vascular, educational and lifestyle factors. Outcomes Final outcomes include associations between early and late life cognition and integrity of key white matter tracts, volume of gray and white matter, myelination, brain water content, and visible abnormalities such as white matter lesions and mineral deposits; and influences of vascular risk factors, diet, environment, social metrics, education and genetics on healthy brain aging. It is intended that this information will help to inform and develop strategies for successful cognitive aging.en_UK
dc.language.isoenen_UK
dc.publisherSAGE Publicationsen_UK
dc.relationWardlaw JM, Bastin ME, Valdés Hernández MC, Maniega SM, Royle NA, Morris Z, Clayden JD, Sandeman EM, Eadie E, Murray C, Starr JM & Deary IJ (2011) Brain Ageing, Cognition in Youth and Old Age and Vascular Disease in the Lothian Birth Cohort 1936: Rationale, Design and Methodology of the Imaging Protocol. International Journal of Stroke, 6 (6), pp. 547-559. https://doi.org/10.1111/j.1747-4949.2011.00683.xen_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_UK
dc.subjectBrainen_UK
dc.subjectMRIen_UK
dc.subjectnormal ageingen_UK
dc.titleBrain Ageing, Cognition in Youth and Old Age and Vascular Disease in the Lothian Birth Cohort 1936: Rationale, Design and Methodology of the Imaging Protocolen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-31en_UK
dc.rights.embargoreason[Wardlaw et al 2011.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.doi10.1111/j.1747-4949.2011.00683.xen_UK
dc.identifier.pmid22111801en_UK
dc.citation.jtitleInternational Journal of Strokeen_UK
dc.citation.issn1747-4949en_UK
dc.citation.issn1747-4930en_UK
dc.citation.volume6en_UK
dc.citation.issue6en_UK
dc.citation.spage547en_UK
dc.citation.epage559en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderMedical Research Councilen_UK
dc.contributor.funderEconomic and Social Research Councilen_UK
dc.contributor.funderEngineering and Physical Sciences Research Councilen_UK
dc.contributor.funderBiotechnology and Biological Sciences Research Councilen_UK
dc.author.emailcatherine.murray@stir.ac.uken_UK
dc.citation.date24/11/2011en_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity College Londonen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationNHS Lothianen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.identifier.isiWOS:000297313800014en_UK
dc.identifier.scopusid2-s2.0-82255186198en_UK
dc.identifier.wtid917592en_UK
dcterms.dateAccepted2011-11-24en_UK
dc.date.filedepositdate2018-08-09en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorWardlaw, Joanna M|en_UK
local.rioxx.authorBastin, Mark E|en_UK
local.rioxx.authorValdés Hernández, Maria C|en_UK
local.rioxx.authorManiega, Susana Muñoz|en_UK
local.rioxx.authorRoyle, Natalie A|en_UK
local.rioxx.authorMorris, Zoe|en_UK
local.rioxx.authorClayden, Jonathan D|en_UK
local.rioxx.authorSandeman, Elaine M|en_UK
local.rioxx.authorEadie, Elizabeth|en_UK
local.rioxx.authorMurray, Catherine|en_UK
local.rioxx.authorStarr, John M|en_UK
local.rioxx.authorDeary, Ian J|en_UK
local.rioxx.projectProject ID unknown|Economic and Social Research Council|http://dx.doi.org/10.13039/501100000269en_UK
local.rioxx.projectProject ID unknown|Biotechnology and Biological Sciences Research Council|http://dx.doi.org/10.13039/501100000268en_UK
local.rioxx.projectProject ID unknown|Engineering and Physical Sciences Research Council|http://dx.doi.org/10.13039/501100000266en_UK
local.rioxx.projectProject ID unknown|Medical Research Council|http://dx.doi.org/10.13039/501100000265en_UK
local.rioxx.freetoreaddate2261-10-25en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||en_UK
local.rioxx.filenameWardlaw et al 2011.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1747-4949en_UK
Appears in Collections:Psychology Journal Articles

Files in This Item:
File Description SizeFormat 
Wardlaw et al 2011.pdfFulltext - Published Version1.81 MBAdobe PDFUnder Permanent Embargo    Request a copy


This item is protected by original copyright



Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

The metadata of the records in the Repository are available under the CC0 public domain dedication: No Rights Reserved https://creativecommons.org/publicdomain/zero/1.0/

If you believe that any material held in STORRE infringes copyright, please contact library@stir.ac.uk providing details and we will remove the Work from public display in STORRE and investigate your claim.