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Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/27637
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dc.contributor.authorPenke, Larsen_UK
dc.contributor.authorMuñoz Maniega, Susanaen_UK
dc.contributor.authorHoulihan, Lorna Men_UK
dc.contributor.authorMurray, Catherineen_UK
dc.contributor.authorGow, Alan Jen_UK
dc.contributor.authorClayden, Jonathan Den_UK
dc.contributor.authorBastin, Mark Een_UK
dc.contributor.authorWardlaw, Joanna Men_UK
dc.contributor.authorDeary, Ian Jen_UK
dc.date.accessioned2018-08-17T00:15:13Z-
dc.date.available2018-08-17T00:15:13Z-
dc.date.issued2010-03-31en_UK
dc.identifier.urihttp://hdl.handle.net/1893/27637-
dc.description.abstractIt has recently been reported that the evolutionarily ancestral alleles of two functional polymorphisms in the β2-adrenergic receptor gene (ADRB2) were related to higher cognitive ability in the 70 year old participants of the Lothian Birth Cohort 1936 (LBC1936). One emerging important factor in cognitive aging is the integrity of white matter tracts in the brain. Here, we used diffusion tensor MRI-based tractography to assess the integrity of eight white matter tracts in a subsample of the LBC1936. Higher integrity of the splenium of the corpus callosum predicted better cognitive ability in old age, even after controlling for IQ at age 11. Also, the ancestral allele of one ADRB2 SNP was associated with both splenium integrity and better cognitive aging. While the effects of the SNP and splenium integrity on cognitive aging were largely independent, there was some evidence for a partial mediation effect of ADRB2 status via splenium integrity.en_UK
dc.language.isoenen_UK
dc.publisherSpringer Natureen_UK
dc.relationPenke L, Muñoz Maniega S, Houlihan LM, Murray C, Gow AJ, Clayden JD, Bastin ME, Wardlaw JM & Deary IJ (2010) White Matter Integrity in the Splenium of the Corpus Callosum is Related to Successful Cognitive Aging and Partly Mediates the Protective Effect of an Ancestral Polymorphism in ADRB2. Behavior Genetics, 40 (2), pp. 146-156. https://doi.org/10.1007/s10519-009-9318-4en_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_UK
dc.subjectCognitive agingen_UK
dc.subjectdiffusion tensor MRIen_UK
dc.subjectwhite matter tractographyen_UK
dc.subjectsplenium corpus callosumen_UK
dc.subjectADRB2en_UK
dc.subjectcomparative genomicsen_UK
dc.titleWhite Matter Integrity in the Splenium of the Corpus Callosum is Related to Successful Cognitive Aging and Partly Mediates the Protective Effect of an Ancestral Polymorphism in ADRB2en_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-31en_UK
dc.rights.embargoreason[Penke et al 2010_WhiteMatterIntegrity.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.doi10.1007/s10519-009-9318-4en_UK
dc.identifier.pmid20087642en_UK
dc.citation.jtitleBehavior Geneticsen_UK
dc.citation.issn1573-3297en_UK
dc.citation.issn0001-8244en_UK
dc.citation.volume40en_UK
dc.citation.issue2en_UK
dc.citation.spage146en_UK
dc.citation.epage156en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderMedical Research Councilen_UK
dc.author.emailcatherine.murray@stir.ac.uken_UK
dc.citation.date20/01/2010en_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity College Londonen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.identifier.isiWOS:000274964000005en_UK
dc.identifier.scopusid2-s2.0-77949267639en_UK
dc.identifier.wtid909360en_UK
dc.date.accepted2009-11-21en_UK
dcterms.dateAccepted2009-11-21en_UK
dc.date.filedepositdate2018-08-09en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorPenke, Lars|en_UK
local.rioxx.authorMuñoz Maniega, Susana|en_UK
local.rioxx.authorHoulihan, Lorna M|en_UK
local.rioxx.authorMurray, Catherine|en_UK
local.rioxx.authorGow, Alan J|en_UK
local.rioxx.authorClayden, Jonathan D|en_UK
local.rioxx.authorBastin, Mark E|en_UK
local.rioxx.authorWardlaw, Joanna M|en_UK
local.rioxx.authorDeary, Ian J|en_UK
local.rioxx.projectProject ID unknown|Medical Research Council|http://dx.doi.org/10.13039/501100000265en_UK
local.rioxx.freetoreaddate2259-12-21en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||en_UK
local.rioxx.filenamePenke et al 2010_WhiteMatterIntegrity.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1573-3297en_UK
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