Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/27590
Appears in Collections:Biological and Environmental Sciences Journal Articles
Peer Review Status: Refereed
Title: Apical Function in Neocortical Pyramidal Cells: A Common Pathway by Which General Anesthetics Can Affect Mental State
Author(s): Phillips, William A
Bachmann, Talis
Storm, Johan F
Keywords: general anesthesia
neocortical pyramidal cells
apical amplification
neural correlates of consciousness
noradrenergic arousal
thalamus
Issue Date: 2-Jul-2018
Citation: Phillips WA, Bachmann T & Storm JF (2018) Apical Function in Neocortical Pyramidal Cells: A Common Pathway by Which General Anesthetics Can Affect Mental State, Frontiers in Neural Circuits, 12, Art. No.: 50. https://doi.org/10.3389/fncir.2018.00050.
Abstract: It has been argued that general anesthetics suppress the level of consciousness, or the contents of consciousness, or both. The distinction between level and content is important because, in addition to clarifying the mechanisms of anesthesia, it may help clarify the neural bases of consciousness. We assess these arguments in the light of evidence that both the level and the content of consciousness depend upon the contribution of apical input to the information processing capabilities of neocortical pyramidal cells which selectively amplify relevant signals. We summarize research suggesting that what neocortical pyramidal cells transmit information about can be distinguished from levels of arousal controlled by sub-cortical nuclei and from levels of prioritization specified by interactions within the thalamocortical system. Put simply, on the basis of the observations reviewed, we hypothesize that when conscious we have particular, directly experienced, percepts, thoughts, feelings and intentions, and that general anesthetics affect consciousness by interfering with the subcellular processes by which particular activities are selectively amplified when relevant to the current context.
DOI Link: 10.3389/fncir.2018.00050
Rights: © 2018 Phillips, Bachmann and Storm. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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