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Appears in Collections:Biological and Environmental Sciences Journal Articles
Peer Review Status: Refereed
Title: Age-related dataset on the mechanical properties and collagen fibril structure of tendons from a murine model
Author(s): Goh, Kheng Lim
Holmes, David F
Lu, Yin Hui
Kadler, Karl E
Purslow, Peter P
Issue Date: 31-Dec-2018
Citation: Goh KL, Holmes DF, Lu YH, Kadler KE & Purslow PP (2018) Age-related dataset on the mechanical properties and collagen fibril structure of tendons from a murine model. Scientific Data, 5, Art. No.: 180140.
Abstract: Connective tissues such as tendon, ligament and skin are biological fibre composites comprising collagen fibrils reinforcing the weak proteoglycan-rich ground substance in extracellular matrix (ECM). One of the hallmarks of ageing of connective tissues is the progressive and irreversible change in the tissue mechanical properties; this is often attributed to the underlying changes to the collagen fibril structure. This dataset represents a comprehensive screen of the mechanical properties and collagen fibril structure of tendon from the tails of young to old (i.e. 1.6–35.3 month-old) C57BL6/B mice. The mechanical portion consists of the load-displacement data, as well as the derived tensile properties; the structure data consists of transmission electron micrographs of collagen fibril cross section, as well as the derived cross-sectional parameters. This dataset will allow other researchers to develop and demonstrate the utility of innovative multiscale models and approaches of the extra-cellular and physiological events of ageing of current interest to ageing research, by reducing the current reliance on conducting new mammalian experiments.
DOI Link: 10.1038/sdata.2018.140
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