Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/27581
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dc.contributor.authorChalmers, Lynnen_UK
dc.contributor.authorVera, Luisa Men_UK
dc.contributor.authorTaylor, John Fen_UK
dc.contributor.authorAdams, Alexandraen_UK
dc.contributor.authorMigaud, Herveen_UK
dc.date.accessioned2018-08-01T13:51:59Z-
dc.date.available2018-08-01T13:51:59Z-
dc.date.issued2018-10-31en_UK
dc.identifier.urihttp://hdl.handle.net/1893/27581-
dc.description.abstractWhile research into the growth, survival, nutrition and, more recently, disease susceptibility of triploid Atlantic salmon has expanded, there remains an overall lack of studies assessing the response of triploids to chemical treatments. It is essential that the response of triploids to disease treatments be characterised to validate their suitability for commercial production. This study aimed to investigate and compare the stress and immune responses of triploid and diploid Atlantic salmon following an experimental treatment with hydrogen peroxide (H2O2). A dose response test was first undertaken to determine a suitable test dose for both diploid and triploid Atlantic salmon. Following this, diploids and triploids were exposed to H2O2 (1800 ppm) for 20 min, as per commercial practices, after which blood glucose and lactate, and plasma cortisol and lysozyme were measured, along with the expression of oxidative stress and immune-related genes. In the first 6 h post-exposure to H2O2, comparable mortalities occurred in both diploid and triploid Atlantic salmon. Cortisol, glucose and lactate were not significantly influenced by ploidy suggesting that, physiologically, triploid Atlantic salmon are able to cope with the stress associated with H2O2 exposure as well as their diploid counterparts. Exposure to H2O2 significantly elevated the expression of cat and sod2 in diploid livers and gr, il1β and crp/sap1b in diploid gills, while it significantly decreased the expression of saa5 and crp/sap1a in diploid gills. In triploids, the expression levels of cat, hsp70, sod1, saa5, crp/sap1a and crp/sap1b in liver was significantly higher in fish exposed to H2O2 compared to control fish. The expression of gr, sod1 and il1β in triploid gills was also elevated in response to H2O2 exposure. This study represents the first experimental evidence of the effects of H2O2 exposure on triploid Atlantic salmon and continues to support their application into commercial production.en_UK
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.relationChalmers L, Vera LM, Taylor JF, Adams A & Migaud H (2018) Comparative ploidy response to experimental hydrogen peroxide exposure in Atlantic salmon (Salmo salar). Fish and Shellfish Immunology, 81, pp. 354-367. https://doi.org/10.1016/j.fsi.2018.07.017en_UK
dc.rightsThis article is available under the terms of the Creative Commons Attribution License (CC BY). You may copy and distribute the article, create extracts, abstracts and new works from the article, alter and revise the article, text or data mine the article and otherwise reuse the article commercially (including reuse and/or resale of the article) without permission from Elsevier. You must give appropriate credit to the original work, together with a link to the formal publication through the relevant DOI and a link to the Creative Commons user license above. You must indicate if any changes are made but not in any way that suggests the licensor endorses you or your use of the work.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.subjectTriploiden_UK
dc.subjectAtlantic salmonen_UK
dc.subjectH2O2en_UK
dc.subjectStressen_UK
dc.subjectGene expressionen_UK
dc.subjectImmune responseen_UK
dc.titleComparative ploidy response to experimental hydrogen peroxide exposure in Atlantic salmon (Salmo salar)en_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1016/j.fsi.2018.07.017en_UK
dc.identifier.pmid30012493en_UK
dc.citation.jtitleFish and Shellfish Immunologyen_UK
dc.citation.issn1050-4648en_UK
dc.citation.volume81en_UK
dc.citation.spage354en_UK
dc.citation.epage367en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderBiotechnology and Biological Sciences Research Councilen_UK
dc.citation.date25/07/2018en_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.identifier.isiWOS:000443665900041en_UK
dc.identifier.scopusid2-s2.0-85050356619en_UK
dc.identifier.wtid963517en_UK
dc.contributor.orcid0000-0002-1271-2991en_UK
dc.contributor.orcid0000-0003-0999-055Xen_UK
dc.contributor.orcid0000-0003-4370-7922en_UK
dc.contributor.orcid0000-0002-5404-7512en_UK
dc.date.accepted2018-07-10en_UK
dcterms.dateAccepted2018-07-10en_UK
dc.date.filedepositdate2018-08-01en_UK
rioxxterms.apcpaiden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorChalmers, Lynn|0000-0002-1271-2991en_UK
local.rioxx.authorVera, Luisa M|0000-0003-0999-055Xen_UK
local.rioxx.authorTaylor, John F|0000-0003-4370-7922en_UK
local.rioxx.authorAdams, Alexandra|en_UK
local.rioxx.authorMigaud, Herve|0000-0002-5404-7512en_UK
local.rioxx.projectProject ID unknown|Biotechnology and Biological Sciences Research Council|http://dx.doi.org/10.13039/501100000268en_UK
local.rioxx.freetoreaddate2018-08-01en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by/4.0/|2018-08-01|en_UK
local.rioxx.filename1-s2.0-S1050464818304157-main.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1050-4648en_UK
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