Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/27555
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dc.contributor.authorLyall, Donald Men_UK
dc.contributor.authorRoyle, Natalie Aen_UK
dc.contributor.authorHarris, Sarah Een_UK
dc.contributor.authorBastin, Mark Een_UK
dc.contributor.authorManiega, Susana Muñozen_UK
dc.contributor.authorMurray, Catherineen_UK
dc.contributor.authorLutz, Michael Wen_UK
dc.contributor.authorSaunders, Ann Men_UK
dc.contributor.authorRoses, Allen Den_UK
dc.contributor.authordel Valdés Hernández, Maria Cen_UK
dc.contributor.authorStarr, John Men_UK
dc.contributor.authorPorteous, David Jen_UK
dc.contributor.authorWardlaw, Joanna Men_UK
dc.contributor.authorDeary, Ian Jen_UK
dc.date.accessioned2018-07-25T00:04:51Z-
dc.date.available2018-07-25T00:04:51Z-
dc.date.issued2013-11-15en_UK
dc.identifier.urihttp://hdl.handle.net/1893/27555-
dc.description.abstractThe APOE ε and TOMM40 rs10524523 (‘523’) variable length poly-T repeat gene loci have been significantly and independently associated with Alzheimer’s disease (AD) related phenotypes such as age of clinical onset. Hippocampal atrophy has been significantly associated with memory impairment, a characteristic of AD. The current study aimed to test for independent effects of APOE ε and TOMM40 ‘523’ genotypes on hippocampal volumes as assessed by brain structural MRI in a relatively large sample of community-dwelling older adults. As part of a longitudinal study of cognitive ageing, participants in the Lothian Birth Cohort 1936 underwent genotyping for APOE ε2/ε3/ε4 status and TOMM40 ‘523’ poly-T repeat length, and detailed structural brain MRI at a mean age of 72.7 years (standard deviation = 0.7, N range = 624 to 636). No significant effects of APOE ε or TOMM40 523 genotype were found on hippocampal volumes when analysed raw, or when adjusted for either intracranial or total brain tissue volumes. In summary, in a large community-dwelling sample of older adults, we found no effects of APOE ε or TOMM40 523 genotypes on hippocampal volumes. This is discrepant with some previous reports of significant association between APOE and left/right hippocampal volumes, and instead echoes other reports that found no association. Previous significant findings may partly reflect type 1 error. Future studies should carefully consider: 1) their specific techniques in adjusting for brain size; 2) assessing more detailed sub-divisions of the hippocampal formation; and 3) testing whether significant APOE-hippocampal associations are independent of generalised brain atrophy.en_UK
dc.language.isoenen_UK
dc.publisherPublic Library of Science (PLoS)en_UK
dc.relationLyall DM, Royle NA, Harris SE, Bastin ME, Maniega SM, Murray C, Lutz MW, Saunders AM, Roses AD, del Valdés Hernández MC, Starr JM, Porteous DJ, Wardlaw JM & Deary IJ (2013) Alzheimer’s Disease Susceptibility Genes APOE and TOMM40, and Hippocampal Volumes in the Lothian Birth Cohort 1936, PLoS ONE, 8 (11), p. e80513. https://doi.org/10.1371/journal.pone.0080513.en_UK
dc.rights© 2013 Lyall et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_UK
dc.titleAlzheimer’s Disease Susceptibility Genes APOE and TOMM40, and Hippocampal Volumes in the Lothian Birth Cohort 1936en_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1371/journal.pone.0080513en_UK
dc.identifier.pmid24260406en_UK
dc.citation.jtitlePLoS ONEen_UK
dc.citation.issn1932-6203en_UK
dc.citation.volume8en_UK
dc.citation.issue11en_UK
dc.citation.spagee80513en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderMedical Research Councilen_UK
dc.contributor.funderEconomic and Social Research Councilen_UK
dc.contributor.funderEngineering and Physical Sciences Research Councilen_UK
dc.contributor.funderBiotechnology and Biological Sciences Research Councilen_UK
dc.contributor.funderScottish Funding Councilen_UK
dc.contributor.funderAge UKen_UK
dc.citation.date15/11/2013en_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationDuke Universityen_UK
dc.contributor.affiliationDuke Universityen_UK
dc.contributor.affiliationDuke Universityen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.identifier.isi000327258600067en_UK
dc.identifier.scopusid2-s2.0-84894034271en_UK
dc.identifier.wtid917979en_UK
dc.date.accepted2013-10-04en_UK
dc.date.firstcompliantdepositdate2018-07-06en_UK
Appears in Collections:Psychology Journal Articles

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