Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/27548
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dc.contributor.authorValdés Hernández, Maria Cen_UK
dc.contributor.authorPiper, Rory Jen_UK
dc.contributor.authorBastin, Mark Een_UK
dc.contributor.authorRoyle, Natalie Aen_UK
dc.contributor.authorMuñoz Maniega, Susanaen_UK
dc.contributor.authorAribisala, Benjamin Sen_UK
dc.contributor.authorMurray, Catherineen_UK
dc.contributor.authorDeary, Ian Jen_UK
dc.contributor.authorWardlaw, Joanna Men_UK
dc.date.accessioned2018-07-25T00:02:33Z-
dc.date.available2018-07-25T00:02:33Z-
dc.date.issued2013-12-31en_UK
dc.identifier.urihttp://hdl.handle.net/1893/27548-
dc.description.abstractBackground and purpose: White matter hyperintensities are characteristic of old age and identifiable on FLAIR and T2-weighted MR imaging. They are typically separated into periventricular or deep categories. It is unclear whether the innermost segment of periventricular white matter hyperintensities is truly abnormal or is imaging artifacts. Materials and methods: We used FLAIR MR imaging from 665 community-dwelling subjects 72–73 years of age without dementia. Periventricular white matter hyperintensities were visually allocated into 4 categories: 1) thin white line; 2) thick rim; 3) penetrating toward or confluent with deep white matter hyperintensities; and 4) diffuse ill-defined, labeled as "subtle extended periventricular white matter hyperintensities." We measured the maximum intensity and width of the periventricular white matter hyperintensities, mapped all white matter hyperintensities in 3D, and investigated associations between each category and hypertension, stroke, diabetes, hypercholesterolemia, cardiovascular disease, and total white matter hyperintensity volume. Results: The intensity patterns and morphologic features were different for each periventricular white matter hyperintensity category. Both the widths (r = 0.61, P < .001) and intensities (r = 0.51, P < .001) correlated with total white matter hyperintensity volume and with each other (r = 0.55, P < .001) for all categories with the exception of subtle extended periventricular white matter hyperintensities, largely characterized by evidence of erratic, ill-defined, and fragmented pale white matter hyperintensities (width: r = 0.02, P = .11; intensity: r = 0.02, P = .84). The prevalence of hypertension, hypercholesterolemia, and neuroradiologic evidence of stroke increased from periventricular white matter hyperintensity categories 1 to 3. The mean periventricular white matter hyperintensity width was significantly larger in subjects with hypertension (mean difference = 0.5 mm, P = .029) or evidence of stroke (mean difference = 1 mm, P < .001). 3D mapping revealed that periventricular white matter hyperintensities were discontinuous with deep white matter hyperintensities in all categories, except only in particular regions in brains with category 3. Conclusions: Periventricular white matter hyperintensity intensity levels, distribution, and association with risk factors and disease suggest that in old age, these are true tissue abnormalities and therefore should not be dismissed as artifacts. Dichotomizing periventricular and deep white matter hyperintensities by continuity from the ventricle edge toward the deep white matter is possible.en_UK
dc.language.isoenen_UK
dc.publisherAmerican Society of Neuroradiology (ASNR)en_UK
dc.relationHernández MV, Piper R, Bastin M, Royle N, Maniega SM, Aribisala B, Murray C, Deary I & Wardlaw J (2013) Morphologic, Distributional, Volumetric, and Intensity Characterization of Periventricular Hyperintensities, American Journal of Neuroradiology, 35 (1), pp. 55-62. https://doi.org/10.3174/ajnr.a3612.en_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.titleMorphologic, Distributional, Volumetric, and Intensity Characterization of Periventricular Hyperintensitiesen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-31en_UK
dc.rights.embargoreason[Valdes Hernandez et al 2013.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.doi10.3174/ajnr.a3612en_UK
dc.identifier.pmid23811980en_UK
dc.citation.jtitleAmerican Journal of Neuroradiologyen_UK
dc.citation.issn1936-959Xen_UK
dc.citation.issn0195-6108en_UK
dc.citation.volume35en_UK
dc.citation.issue1en_UK
dc.citation.spage55en_UK
dc.citation.epage62en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderMedical Research Councilen_UK
dc.contributor.funderAge UKen_UK
dc.author.emailcatherine.murray@stir.ac.uken_UK
dc.citation.date27/06/2013en_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.identifier.isi000333568100012en_UK
dc.identifier.scopusid2-s2.0-84892724920en_UK
dc.identifier.wtid918163en_UK
dc.date.accepted2013-03-21en_UK
dc.date.firstcompliantdepositdate2018-07-06en_UK
Appears in Collections:Psychology Journal Articles

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