Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/27532
Full metadata record
DC FieldValueLanguage
dc.contributor.authorRoyle, Natalie Aen_UK
dc.contributor.authorBooth, Tomen_UK
dc.contributor.authorValdés Hernández, Maria Cen_UK
dc.contributor.authorPenke, Larsen_UK
dc.contributor.authorMurray, Catherineen_UK
dc.contributor.authorGow, Alan Jen_UK
dc.contributor.authorManiega, Susana Muñozen_UK
dc.contributor.authorStarr, Johnen_UK
dc.contributor.authorBastin, Mark Een_UK
dc.contributor.authorDeary, Ian Jen_UK
dc.contributor.authorWardlaw, Joanna Men_UK
dc.date.accessioned2018-07-24T00:03:04Z-
dc.date.available2018-07-24T00:03:04Z-
dc.date.issued2013-12-31en_UK
dc.identifier.urihttp://hdl.handle.net/1893/27532-
dc.description.abstractBrain tissue deterioration is a significant contributor to lower cognitive ability in later life; however, few studies have appropriate data to establish how much influence prior brain volume and prior cognitive performance have on this association. We investigated the associations between structural brain imaging biomarkers, including an estimate of maximal brain volume, and detailed measures of cognitive ability at age 73 years in a large (N = 620), generally healthy, community-dwelling population. Cognitive ability data were available from age 11 years. We found positive associations (r) between general cognitive ability and estimated brain volume in youth (male, 0.28; females, 0.12), and in measured brain volume in later life (males, 0.27; females, 0.26). Our findings show that cognitive ability in youth is a strong predictor of estimated prior and measured current brain volume in old age but that these effects were the same for both white and gray matter. As 1 of the largest studies of associations between brain volume and cognitive ability with normal aging, this work contributes to the wider understanding of how some early-life factors influence cognitive aging.en_UK
dc.language.isoenen_UK
dc.publisherElsevier BVen_UK
dc.relationRoyle NA, Booth T, Valdés Hernández MC, Penke L, Murray C, Gow AJ, Maniega SM, Starr J, Bastin ME, Deary IJ & Wardlaw JM (2013) Estimated maximal and current brain volume predict cognitive ability in old age, Neurobiology of Aging, 34 (12), pp. 2726-2733. https://doi.org/10.1016/j.neurobiolaging.2013.05.015.en_UK
dc.rightsThis article is available under the terms of the Creative Commons Attribution License (CC BY). (https://creativecommons.org/licenses/by/3.0/) You may distribute and copy the article, create extracts, abstracts, and other revised versions, adaptations or derivative works of or from an article (such as a translation), to include in a collective work (such as an anthology), to text or data mine the article, including for commercial purposes without permission from Elsevier. The original work must always be appropriately credited.en_UK
dc.subjectAgingen_UK
dc.subjectstructural brain imaging biomarkersen_UK
dc.subjectbrain volumeen_UK
dc.subjectlife course cognitive abilityen_UK
dc.subjectIQen_UK
dc.titleEstimated maximal and current brain volume predict cognitive ability in old ageen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1016/j.neurobiolaging.2013.05.015en_UK
dc.identifier.pmid23850342en_UK
dc.citation.jtitleNeurobiology of Agingen_UK
dc.citation.issn0197-4580en_UK
dc.citation.volume34en_UK
dc.citation.issue12en_UK
dc.citation.spage2726en_UK
dc.citation.epage2733en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderMedical Research Councilen_UK
dc.contributor.funderEconomic and Social Research Councilen_UK
dc.contributor.funderEngineering and Physical Sciences Research Councilen_UK
dc.contributor.funderBiotechnology and Biological Sciences Research Councilen_UK
dc.citation.date11/07/2013en_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.identifier.isi000326657800003en_UK
dc.identifier.scopusid2-s2.0-84884132637en_UK
dc.identifier.wtid917913en_UK
dc.date.accepted2013-05-16en_UK
dc.date.firstcompliantdepositdate2018-07-06en_UK
Appears in Collections:Psychology Journal Articles

Files in This Item:
File Description SizeFormat 
Royle et al 2013.pdfFulltext - Published Version647.77 kBAdobe PDFView/Open


This item is protected by original copyright



Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

If you believe that any material held in STORRE infringes copyright, please contact library@stir.ac.uk providing details and we will remove the Work from public display in STORRE and investigate your claim.