|Appears in Collections:||Aquaculture Journal Articles|
|Peer Review Status:||Refereed|
|Title:||Safe limits of selenomethionine and selenite supplementation to plant-based Atlantic salmon feeds|
|Author(s):||Berntssen, Marc H G|
Caballero, Maria Jose
Bench mark dose
|Citation:||Berntssen MHG, Betancor M, Caballero MJ, Hillestad M, Rasinger J, Hamre K, Sele V, Amlund H & Ørnsrud R (2018) Safe limits of selenomethionine and selenite supplementation to plant-based Atlantic salmon feeds, Aquaculture, 495, pp. 617-630. https://doi.org/10.1016/j.aquaculture.2018.06.041.|
|Abstract:||The use of plant-based feeds warrants the supplementation with selenium (Se) to cover the requirement for Atlantic salmon. Depending on its chemical form, Se is a trace element with a narrow range between requirement and toxicity for most vertebrates. Information on safe upper limit for Atlantic salmon feed supplementation is lacking. Atlantic salmon (147 g) were fed a low natural background organic Se diet (0.45 mg Se kg−1, wet weight (ww)) fortified with 5 graded levels of inorganic sodium selenite (0.45, 5.4, 11.0, 29.4, or 60.0 mg kg−1 ww) or organic selenomethionine (SeMet) (0.45, 6.2, 16.2, 21, or 39 mg kg−1 ww), in triplicate for 3 months. Excess Se supplementation was assessed by targeted biomarkers of Se toxicity pathways (e.g. markers of oxidative stress and lipid metabolism), as well as general adverse effect parameters (plasma biochemistry, hematology, liver histopathology, and growth). Safe limits were set by model-fitting the effect data in a dose-response (lower bound) bench mark dose (BMDL) evaluation. Fish fed the two highest selenite levels showed mortality while fish fed SeMet had no mortality. Fish fed 5.4–11 mg selenite kg−1 feed showed significantly (ANOVA, Tukey's t-test, p|
|Rights:||© 2018 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license|
|1-s2.0-S0044848618309244-main.pdf||Fulltext - Published Version||1.68 MB||Adobe PDF||View/Open|
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