Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/2745
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dc.contributor.authorLeaver, Michaelen_UK
dc.contributor.authorTaggart, Johnen_UK
dc.contributor.authorVilleneuve, Laureen_UK
dc.contributor.authorBron, Jamesen_UK
dc.contributor.authorGuy, Derrick Ren_UK
dc.contributor.authorBishop, Stephen Cen_UK
dc.contributor.authorHouston, Ross Den_UK
dc.contributor.authorMatika, Oswalden_UK
dc.contributor.authorTocher, Douglas Ren_UK
dc.date.accessioned2018-04-26T02:36:12Z-
dc.date.available2018-04-26T02:36:12Z-
dc.date.issued2011-03en_UK
dc.identifier.urihttp://hdl.handle.net/1893/2745-
dc.description.abstractN-3 long chain polyunsaturated fatty acids (n-3LC-PUFA) are essential components of vertebrate membrane lipids and are crucially deficient in modern Western diets. The main human dietary source for n-3LC-PUFA is fish and seafood, particularly oily fish and over 50% of global fish production is currently supplied by aquaculture. However, increasing pressure to include vegetable oils, which are devoid of n-3LC-PUFA, in aquaculture feeds reduces the content of these crucial nutrients in farmed fish flesh. The aim of this study was to measure the heritability and infer mechanisms determining flesh n-3LC-PUFA content in Atlantic salmon. This was achieved by analysing flesh lipid parameters in 48 families of Atlantic salmon, and by measuring differences in hepatic mRNA expression in families with high and low flesh n-3LC-PUFA. The results show that flesh n-3LC-PUFA level is a highly heritable trait (h2 = 0.77±0.14) and indicate the involvement of increased lipid transport, most likely in the form of very low density lipoprotein (VLDL) from liver. This increase in lipid transport may be associated with increased activity of a transcription factor, hepatic nuclear factor 4α (HNF4α), possibly as a result of family differences in transforming growth factor β1 (Tgfβ1) signalling. This study paves the way for identification of quantitative trait loci and gene interaction networks that are associated with levels of n-3LC-PUFA in fish flesh. Such markers can be used to assist the sustainable production of Atlantic salmon and provide optimal levels of critical nutrients for human consumers.en_UK
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.relationLeaver M, Taggart J, Villeneuve L, Bron J, Guy DR, Bishop SC, Houston RD, Matika O & Tocher DR (2011) Heritability and mechanisms of n-3 long chain polyunsaturated fatty acid deposition in the flesh of Atlantic salmon. Comparative Biochemistry and Physiology - Part D: Genomics and Proteomics, 6 (1), pp. 62-69. http://www.sciencedirect.com/science/journal/1744117X; https://doi.org/10.1016/j.cbd.2010.04.002en_UK
dc.rightsPublished in Comparative Biochemistry and Physiology Part D: Genomics and Proteomics by Elsevier.; Comparative Biochemistry and Physiology Part D: Genomics and Proteomics, Volume 6, Issue 1, March 2011, pp. 62 - 69.en_UK
dc.subjectAtlantic salmonen_UK
dc.subjectfleshen_UK
dc.subjectn-3 long-chain polyunsaturated fatty acidsen_UK
dc.subjecttraiten_UK
dc.subjectheritibilityen_UK
dc.subjectmicroarrayen_UK
dc.subjectliveren_UK
dc.subjectFishes Nutrition Requirementsen_UK
dc.subjectAtlantic Salmonen_UK
dc.titleHeritability and mechanisms of n-3 long chain polyunsaturated fatty acid deposition in the flesh of Atlantic salmonen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1016/j.cbd.2010.04.002en_UK
dc.identifier.pmid20451480en_UK
dc.citation.jtitleComparative Biochemistry and Physiology - Part D: Genomics and Proteomicsen_UK
dc.citation.issn1744-117Xen_UK
dc.citation.volume6en_UK
dc.citation.issue1en_UK
dc.citation.spage62en_UK
dc.citation.epage69en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.identifier.urlhttp://www.sciencedirect.com/science/journal/1744117Xen_UK
dc.author.emaildrt1@stir.ac.uken_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationLandcatch Natural Selection Ltden_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.identifier.isiWOS:000286712700009en_UK
dc.identifier.scopusid2-s2.0-79251642246en_UK
dc.identifier.wtid892962en_UK
dc.contributor.orcid0000-0002-3155-0844en_UK
dc.contributor.orcid0000-0002-3843-9663en_UK
dc.contributor.orcid0000-0003-3544-0519en_UK
dc.contributor.orcid0000-0002-8603-9410en_UK
dcterms.dateAccepted2011-03-31en_UK
dc.date.filedepositdate2011-03-02en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionAMen_UK
local.rioxx.authorLeaver, Michael|0000-0002-3155-0844en_UK
local.rioxx.authorTaggart, John|0000-0002-3843-9663en_UK
local.rioxx.authorVilleneuve, Laure|en_UK
local.rioxx.authorBron, James|0000-0003-3544-0519en_UK
local.rioxx.authorGuy, Derrick R|en_UK
local.rioxx.authorBishop, Stephen C|en_UK
local.rioxx.authorHouston, Ross D|en_UK
local.rioxx.authorMatika, Oswald|en_UK
local.rioxx.authorTocher, Douglas R|0000-0002-8603-9410en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2011-03-31en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||2011-03-31en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/all-rights-reserved|2011-03-31|en_UK
local.rioxx.filenameMLeaverGIA.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1744-117Xen_UK
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