Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/27001
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dc.contributor.authorGillard, Garethen_UK
dc.contributor.authorHarvey, Thomasen_UK
dc.contributor.authorGjuvsland, Arneen_UK
dc.contributor.authorJin, Yangen_UK
dc.contributor.authorThomassen, Magnyen_UK
dc.contributor.authorLien, Sigbjornen_UK
dc.contributor.authorLeaver, Michaelen_UK
dc.contributor.authorTorgerson, Jacoben_UK
dc.contributor.authorHvidsten, Torgeiren_UK
dc.contributor.authorVik, Jon Olaven_UK
dc.contributor.authorSandve, Simenen_UK
dc.date.accessioned2018-04-14T01:15:38Z-
dc.date.available2018-04-14T01:15:38Z-
dc.date.issued2018-03-31en_UK
dc.identifier.urihttp://hdl.handle.net/1893/27001-
dc.description.abstractAtlantic salmon migrates from rivers to sea to feed, grow and develop gonads before returning to spawn in freshwater. The transition to marine habitats is associated with dramatic changes in the environment, including water salinity, exposure to pathogens and shift in dietary lipid availability. Many changes in physiology and metabolism occur across this life‐stage transition, but little is known about the molecular nature of these changes. Here, we use a long‐term feeding experiment to study transcriptional regulation of lipid metabolism in Atlantic salmon gut and liver in both fresh‐ and saltwater. We find that lipid metabolism becomes significantly less plastic to differences in dietary lipid composition when salmon transitions to saltwater and experiences increased dietary lipid availability. Expression of genes in liver relating to lipogenesis and lipid transport decreases overall and becomes less responsive to diet, while genes for lipid uptake in gut become more highly expressed. Finally, analyses of evolutionary consequences of the salmonid‐specific whole‐genome duplication on lipid metabolism reveal several pathways with significantly different (pen_UK
dc.language.isoenen_UK
dc.publisherWiley-Blackwellen_UK
dc.relationGillard G, Harvey T, Gjuvsland A, Jin Y, Thomassen M, Lien S, Leaver M, Torgerson J, Hvidsten T, Vik JO & Sandve S (2018) Life-stage-associated remodelling of lipid metabolism regulation in Atlantic salmon. Molecular Ecology, 27 (5), pp. 1200-1213. https://doi.org/10.1111/mec.14533en_UK
dc.rightsThis item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. This is the peer reviewed version of the following article: Gillard G, Harvey TN, Gjuvsland A, et al. Life‐stage‐associated remodelling of lipid metabolism regulation in Atlantic salmon. Molecular Ecology 2018;27:1200–1213, which has been published in final form at https://doi.org/10.1111/mec.14533. This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.en_UK
dc.subjectadaptationen_UK
dc.subjectfishen_UK
dc.subjectlife stageen_UK
dc.subjectmetabolismen_UK
dc.subjecttranscriptomicsen_UK
dc.titleLife-stage-associated remodelling of lipid metabolism regulation in Atlantic salmonen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreason[Harvey_etal_MolEcol_submission_revised_final.pdf] Publisher requires embargo of 12 months after formal publication.en_UK
dc.identifier.doi10.1111/mec.14533en_UK
dc.identifier.pmid29431879en_UK
dc.citation.jtitleMolecular Ecologyen_UK
dc.citation.issn1365-294Xen_UK
dc.citation.issn0962-1083en_UK
dc.citation.volume27en_UK
dc.citation.issue5en_UK
dc.citation.spage1200en_UK
dc.citation.epage1213en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.author.emailmjl1@stir.ac.uken_UK
dc.citation.date12/02/2018en_UK
dc.contributor.affiliationNorwegian University of Life Sciencesen_UK
dc.contributor.affiliationNorwegian University of Life Sciencesen_UK
dc.contributor.affiliationNorwegian University of Life Sciencesen_UK
dc.contributor.affiliationNorwegian University of Life Sciencesen_UK
dc.contributor.affiliationNorwegian University of Life Sciencesen_UK
dc.contributor.affiliationNorwegian University of Life Sciencesen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationNorwegian University of Life Sciencesen_UK
dc.contributor.affiliationNorwegian University of Life Sciencesen_UK
dc.contributor.affiliationNorwegian University of Life Sciencesen_UK
dc.contributor.affiliationNorwegian University of Life Sciencesen_UK
dc.identifier.isiWOS:000429575900009en_UK
dc.identifier.scopusid2-s2.0-85043467110en_UK
dc.identifier.wtid877864en_UK
dc.contributor.orcid0000-0002-3155-0844en_UK
dc.date.accepted2017-12-13en_UK
dc.description.refREF Compliant by Deposit in Stirling's Repositoryen_UK
dc.date.filedepositdate2018-04-12en_UK
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