Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/26602
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dc.contributor.authorSow, Abdourahmaneen_UK
dc.contributor.authorFaye, Oumaren_UK
dc.contributor.authorDiallo, Mawlouthen_UK
dc.contributor.authorChen, Rubingen_UK
dc.contributor.authorFaye, Ousmaneen_UK
dc.contributor.authorDiagne, Cheikh Ten_UK
dc.contributor.authorGuerbois, Mathildeen_UK
dc.contributor.authorWeidmann, Manfreden_UK
dc.contributor.authorNdiaye, Youssouphaen_UK
dc.contributor.authorSenghor, Cheikh Sadibouen_UK
dc.contributor.authorFaye, Abdourahmaneen_UK
dc.contributor.authorDiop, Ousmane Men_UK
dc.contributor.authorSadio, Bakaryen_UK
dc.contributor.authorNdiaye, Oumaren_UK
dc.contributor.authorWatts, Douglasen_UK
dc.date.accessioned2018-03-02T23:22:28Z-
dc.date.available2018-03-02T23:22:28Z-
dc.date.issued2018-01en_UK
dc.identifier.otherofx259en_UK
dc.identifier.urihttp://hdl.handle.net/1893/26602-
dc.description.abstractBackground  In Senegal, Chikungunya virus (CHIKV), which is an emerging mosquito-borne alphavirus, circulates in a sylvatic and urban/domestic cycle and has caused sporadic human cases and epidemics since 1960s. However, the real impact of the CHIKV sylvatic cycle in humans and mechanisms underlying its emergence still remains unknown.  Methodology  One thousand four hundred nine suspect cases of CHIKV infection, recruited from 5 health facilities located in Kedougou region, south-eastern Senegal, between May 2009 to March 2010, together with 866 serum samples collected from schoolchildren from 4 elementary schools in May and November 2009 from Kedougou were screened for anti-CHIKV immunoglobulin (Ig)M antibodies and, when appropriate, for viral nucleic acid by real-time polymerase chain reaction (rPCR) and virus isolation. In addition, mosquitoes collected in the same area from May 2009 to January 2010 were tested for CHIKV by rPCR and by virus isolation, and 116 monkeys sera collected from March 2010 to May 2010 were tested for anti-CHIKV IgM and neutralizing antibodies.  Results  The main clinical manifestations of the CHIKV suspect cases were headache, myalgia, and arthralgia. Evidence for CHIKV infection was observed in 1.4% (20 of 1409) of patients among suspect cases. No significant difference was observed among age or sex groups. In addition, 25 (2.9%) students had evidence of CHIKV infection in November 2009. Chikungunya virus was detected in 42 pools of mosquitoes, mainly from Aedes furcifer, and 83% of monkeys sampled were seropositive.  Conclusions  Our findings further documented that CHIKV is maintained in a sylvatic transmission cycle among monkeys and Aedes mosquitoes in Kedougou, and humans become infected by exposure to the virus in the forest.en_UK
dc.language.isoenen_UK
dc.publisherOxford University Pressen_UK
dc.relationSow A, Faye O, Diallo M, Chen R, Faye O, Diagne CT, Guerbois M, Weidmann M, Ndiaye Y, Senghor CS, Faye A, Diop OM, Sadio B, Ndiaye O & Watts D (2018) Chikungunya Outbreak in Kedougou, Southeastern Senegal in 2009–2010. Open Forum Infectious Diseases, 5 (1), Art. No.: ofx259. https://doi.org/10.1093/ofid/ofx259en_UK
dc.rights© The Author(s) 2017. Published by Oxford University Press on behalf of Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.comen_UK
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_UK
dc.subjectChikungunya virusen_UK
dc.subjectKedougouen_UK
dc.subjectSenegalen_UK
dc.subjectsylvatic circulationen_UK
dc.subjectOutbreaken_UK
dc.titleChikungunya Outbreak in Kedougou, Southeastern Senegal in 2009–2010en_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1093/ofid/ofx259en_UK
dc.identifier.pmid29354659en_UK
dc.citation.jtitleOpen Forum Infectious Diseasesen_UK
dc.citation.issn2328-8957en_UK
dc.citation.issnNo ISSNen_UK
dc.citation.volume5en_UK
dc.citation.issue1en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.citation.date02/12/2017en_UK
dc.description.notesAdditional co-authors: Kathryn A. Hanley, Anta T Dia, Denis Malvy, Scott C. Weaver, Amadou Alpha Sallen_UK
dc.contributor.affiliationInstitut Pasteur de Dakaren_UK
dc.contributor.affiliationInstitut Pasteur de Dakaren_UK
dc.contributor.affiliationInstitut Pasteuren_UK
dc.contributor.affiliationUniversity of Texas Medical Branchen_UK
dc.contributor.affiliationInstitut Pasteur de Dakaren_UK
dc.contributor.affiliationInstitut Pasteuren_UK
dc.contributor.affiliationUniversity of Texas Medical Branchen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationSaraya Health Districten_UK
dc.contributor.affiliationKedougou Health Districten_UK
dc.contributor.affiliationInstitut Pasteur de Dakaren_UK
dc.contributor.affiliationInstitut Pasteur de Dakaren_UK
dc.contributor.affiliationInstitut Pasteur de Dakaren_UK
dc.contributor.affiliationInstitut Pasteur de Dakaren_UK
dc.contributor.affiliationUniversity of Texas, El Pasoen_UK
dc.identifier.isiWOS:000423832400015en_UK
dc.identifier.scopusid2-s2.0-85044223829en_UK
dc.identifier.wtid501755en_UK
dc.contributor.orcid0000-0002-7063-7491en_UK
dc.date.accepted2017-11-27en_UK
dcterms.dateAccepted2017-11-27en_UK
dc.date.filedepositdate2018-01-30en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorSow, Abdourahmane|en_UK
local.rioxx.authorFaye, Oumar|en_UK
local.rioxx.authorDiallo, Mawlouth|en_UK
local.rioxx.authorChen, Rubing|en_UK
local.rioxx.authorFaye, Ousmane|en_UK
local.rioxx.authorDiagne, Cheikh T|en_UK
local.rioxx.authorGuerbois, Mathilde|en_UK
local.rioxx.authorWeidmann, Manfred|0000-0002-7063-7491en_UK
local.rioxx.authorNdiaye, Youssoupha|en_UK
local.rioxx.authorSenghor, Cheikh Sadibou|en_UK
local.rioxx.authorFaye, Abdourahmane|en_UK
local.rioxx.authorDiop, Ousmane M|en_UK
local.rioxx.authorSadio, Bakary|en_UK
local.rioxx.authorNdiaye, Oumar|en_UK
local.rioxx.authorWatts, Douglas|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2018-01-30en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by-nc-nd/4.0/|2018-01-30|en_UK
local.rioxx.filenameofx259.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source2328-8957en_UK
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