Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/26350
Appears in Collections:Psychology Journal Articles
Peer Review Status: Refereed
Title: Effects of Acute Alcohol Exposure on Layer 5 Pyramidal Neurons of Juvenile Mice
Author(s): Ferrini, Francesco
Dering, Benjamin
De, Giorgio Andrea
Lossi, Laura
Granato, Alberto
Contact Email: b.r.dering@stir.ac.uk
Keywords: Ethanol
Cerebral cortex
Electrophysiology
Pyramidal neurons
Acute slice
mIPSC
Issue Date: May-2018
Citation: Ferrini F, Dering B, De Giorgio A, Lossi L & Granato A (2018) Effects of Acute Alcohol Exposure on Layer 5 Pyramidal Neurons of Juvenile Mice, Cellular and Molecular Neurobiology, 38 (4), pp. 955-963.
Abstract: Early-onset drinking during childhood or preadolescence is a serious social problem. Yet, most of the basic neurobiological research on the acute effects of ethanol has been carried out on adult or early postnatal animals. We studied the effect of alcohol exposure on the basic electrophysiological properties and cell viability of layer 5 pyramidal neurons from the somatosensory cortex of juvenile (P21–P23) C57BL/6N mice. After bath application of 50 mM ethanol to acute slices of the somatosensory cortex, no adverse effects were detected on cells survival, whereas the input resistance and firing rate of layer 5 neurons were significantly reduced. While the effect on the input resistance was reversible, the depressing effect on cell firing remained stable after 6 min of alcohol exposure. Ethanol application did not result in any significant change of mIPSC frequency, amplitude, and rise time. A slight increase of mIPSC decay time was observed after 6 min of ethanol exposure. The molecular mechanisms leading to these alterations and their significance for the physiology of the cerebral cortex are briefly discussed.
DOI Link: http://dx.doi.org/10.1007/s10571-017-0571-4
Rights: This item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. This is a post-peer-review, pre-copyedit version of an article published in Cellular and Molecular Neurobiology published by Springer. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10571-017-0571-4

Files in This Item:
File Description SizeFormat 
CEMN-D-17-00264_R3.pdf684.15 kBAdobe PDFUnder Embargo until 2019-05-01    Request a copy

Note: If any of the files in this item are currently embargoed, you can request a copy directly from the author by clicking the padlock icon above. However, this facility is dependent on the depositor still being contactable at their original email address.



This item is protected by original copyright



Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

If you believe that any material held in STORRE infringes copyright, please contact library@stir.ac.uk providing details and we will remove the Work from public display in STORRE and investigate your claim.