|Appears in Collections:||Psychology Journal Articles|
|Peer Review Status:||Refereed|
|Title:||Effects of Acute Alcohol Exposure on Layer 5 Pyramidal Neurons of Juvenile Mice|
De, Giorgio Andrea
|Citation:||Ferrini F, Dering B, De Giorgio A, Lossi L & Granato A (2018) Effects of Acute Alcohol Exposure on Layer 5 Pyramidal Neurons of Juvenile Mice, Cellular and Molecular Neurobiology, 38 (4), pp. 955-963.|
|Abstract:||Early-onset drinking during childhood or preadolescence is a serious social problem. Yet, most of the basic neurobiological research on the acute effects of ethanol has been carried out on adult or early postnatal animals. We studied the effect of alcohol exposure on the basic electrophysiological properties and cell viability of layer 5 pyramidal neurons from the somatosensory cortex of juvenile (P21–P23) C57BL/6N mice. After bath application of 50 mM ethanol to acute slices of the somatosensory cortex, no adverse effects were detected on cells survival, whereas the input resistance and firing rate of layer 5 neurons were significantly reduced. While the effect on the input resistance was reversible, the depressing effect on cell firing remained stable after 6 min of alcohol exposure. Ethanol application did not result in any significant change of mIPSC frequency, amplitude, and rise time. A slight increase of mIPSC decay time was observed after 6 min of ethanol exposure. The molecular mechanisms leading to these alterations and their significance for the physiology of the cerebral cortex are briefly discussed.|
|Rights:||This item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. This is a post-peer-review, pre-copyedit version of an article published in Cellular and Molecular Neurobiology published by Springer. The final authenticated version is available online at: http://dx.doi.org/10.1007/s10571-017-0571-4|
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