Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/26288
Appears in Collections:Aquaculture Journal Articles
Peer Review Status: Refereed
Title: Population structure and virulence gene profiles of Streptococcus agalactiae collected from different hosts worldwide
Author(s): Morach, Marina
Stephan, Roger
Schmitt, Sarah
Ewers, Christa
Zschock, Michael
Reyes-Velez, Julian
Gilli, Urs
Crespo-Ortiz, Maria del Pilar
Crumlish, Margaret
Gunturu, Revathi
Daubenberger, Claudia A
Ip, Margaret
Regli, Walter
Johler, Sophia
Contact Email: margaret.crumlish@stir.ac.uk
Issue Date: Mar-2018
Citation: Morach M, Stephan R, Schmitt S, Ewers C, Zschock M, Reyes-Velez J, Gilli U, Crespo-Ortiz MdP, Crumlish M, Gunturu R, Daubenberger CA, Ip M, Regli W & Johler S (2018) Population structure and virulence gene profiles of Streptococcus agalactiae collected from different hosts worldwide, European Journal of Clinical Microbiology and Infectious Diseases, 37 (3), pp. 527-536.
Abstract: Streptococcus agalactiae is a leading cause of morbidity and mortality among neonates and causes severe infections in pregnant women and nonpregnant predisposed adults, in addition to various animal species worldwide. Still, information on the population structure of S. agalactiae and the geographical distribution of different clones is limited. Further data are urgently needed to identify particularly successful clones and obtain insights into possible routes of transmission within one host species and across species borders. We aimed to determine the population structure and virulence gene profiles of S. agalactiae strains from a diverse set of sources and geographical origins. To this end, 373 S. agalactiae isolates obtained from humans and animals from five different continents were typed by DNA microarray profiling. A total of 242 different S. agalactiae strains were identified and further analyzed. Particularly successful clonal lineages, hybridization patterns, and strains were identified that were spread across different continents and/or were present in more than one host species. In particular, several strains were detected in both humans and cattle, and several canine strains were also detected in samples from human, bovine, and porcine hosts. The findings of our study suggest that although S. agalactiae is well adapted to various hosts including humans, cattle, dogs, rodents, and fish, interspecies transmission is possible and occurs between humans and cows, dogs, and rabbits. The virulence and resistance gene profiles presented enable new insights into interspecies transmission and make a crucial contribution to the identification of suitable targets for therapeutic agents and vaccines.
DOI Link: http://dx.doi.org/10.1007/s10096-017-3146-x
Rights: This item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. Publisher policy allows this work to be made available in this repository. Accepted for publication in European Journal of Clinical Microbiology and Infectious Diseases published by Springer. The final publication is available at Springer via https://doi.org/10.1007/s10096-017-3146-x

Files in This Item:
File Description SizeFormat 
revised_manuscript_2.pdf293.53 kBAdobe PDFUnder Embargo until 2019-03-01    Request a copy

Note: If any of the files in this item are currently embargoed, you can request a copy directly from the author by clicking the padlock icon above. However, this facility is dependent on the depositor still being contactable at their original email address.



This item is protected by original copyright



Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

If you believe that any material held in STORRE infringes copyright, please contact library@stir.ac.uk providing details and we will remove the Work from public display in STORRE and investigate your claim.