Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/25997
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dc.contributor.authorHoare, Rowenaen_UK
dc.contributor.authorJung, Sung-Juen_UK
dc.contributor.authorNgo, Thao P Hen_UK
dc.contributor.authorBartie, Kerryen_UK
dc.contributor.authorBaily, Johannaen_UK
dc.contributor.authorThompson, Kim Den_UK
dc.contributor.authorAdams, Alexandraen_UK
dc.date.accessioned2017-10-17T23:27:46Z-
dc.date.available2017-10-17T23:27:46Z-
dc.date.issued2019-02en_UK
dc.identifier.urihttp://hdl.handle.net/1893/25997-
dc.description.abstractFlavobacterium psychrophilum is the causative agent of Rainbow Trout Fry Syndrome which has had a major impact on global salmonid aquaculture. Recent outbreaks in Atlantic salmon in Scotland and Chile have added to the need for a vaccine to protect both salmon and trout. At present no licensed vaccines are available in Europe, leaving antibiotics as the only course of action to contain disease outbreaks. Outbreaks generally occur in fry at temperatures between 10 and 15 °C. Recently outbreaks in larger fish have given added impetus to the development of a vaccine which can provide long term protection from this highly heterogeneous pathogen. Most fish injectable vaccines are formulated with oil emulsion adjuvants to induce strong and long lasting immunity, but which are known to cause side effects. Alternative adjuvants are currently sought to minimise these adverse effects.  The current study was performed to assess the efficacy of a polyvalent, whole cell vaccine containing formalin-inactivated F. psychrophilum to induce protective immunity in Atlantic salmon. The vaccine was formulated with an adjuvant containing squalene and aluminium hydroxide, and was compared to a vaccine formulated with a traditional oil adjuvant, Montanide ISA 760VG, and a non-adjuvanted vaccine. Duplicate groups of salmon (23.5 ± 6.8 g) were vaccinated with each of the vaccine formulations or phosphate buffered saline by intraperitoneal injection. Fish were challenged by intramuscular injection with F. psychrophilum six weeks post-vaccination to test the efficacy of the vaccines. Cumulative mortality reached 70% in the control salmon, while the groups of salmon that received vaccine had significantly lower mortality than the controls (p = 0.0001), with no significant difference in survival between vaccinated groups. The squalene/alum adjuvant was safe, more readily metabolised by the fish and induced less histopathological changes than the traditional oil adjuvant.en_UK
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.relationHoare R, Jung S, Ngo TPH, Bartie K, Baily J, Thompson KD & Adams A (2019) Efficacy and safety of a non-mineral oil adjuvanted injectable vaccine for the protection of Atlantic salmon (Salmo salar L.) against Flavobacterium psychrophilum. Fish and Shellfish Immunology, 85, pp. 44-51. https://doi.org/10.1016/j.fsi.2017.10.005en_UK
dc.rightsThis item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. Accepted refereed manuscript of: Hoare R, Jung S, Ngo TPH, Bartie K, Baily J, Thompson KD & Adams A (2019) Efficacy and safety of a non-mineral oil adjuvanted injectable vaccine for the protection of Atlantic salmon (Salmo salar L.) against Flavobacterium psychrophilum. Fish and Shellfish Immunology, 85, pp. 44-51. DOI: https://doi.org/10.1016/j.fsi.2017.10.005 © 2017, Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/en_UK
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_UK
dc.subjectFlavobacterium psychrophilumen_UK
dc.subjectRTFSen_UK
dc.subjectVaccineen_UK
dc.subjectSalmonen_UK
dc.subjectAdjuvanten_UK
dc.titleEfficacy and safety of a non-mineral oil adjuvanted injectable vaccine for the protection of Atlantic salmon (Salmo salar L.) against Flavobacterium psychrophilumen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreason[Fp_Salmon Vaccination_FSI_accep.pdf] Publisher requires embargo of 12 months after formal publication.en_UK
dc.identifier.doi10.1016/j.fsi.2017.10.005en_UK
dc.identifier.pmid29017943en_UK
dc.citation.jtitleFish and Shellfish Immunologyen_UK
dc.citation.issn1050-4648en_UK
dc.citation.volume85en_UK
dc.citation.spage44en_UK
dc.citation.epage51en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.contributor.funderEuropean Commissionen_UK
dc.author.emailrh30@stir.ac.uken_UK
dc.citation.date07/10/2017en_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationUniversity of Stirlingen_UK
dc.contributor.affiliationUniversity of Stirlingen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationThe Moredun Research Instituteen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.identifier.isiWOS:000457504400006en_UK
dc.identifier.scopusid2-s2.0-85034980208en_UK
dc.identifier.wtid516529en_UK
dc.contributor.orcid0000-0002-9298-4275en_UK
dc.contributor.orcid0000-0003-3037-5295en_UK
dc.contributor.orcid0000-0002-2242-7078en_UK
dc.date.accepted2017-10-06en_UK
dcterms.dateAccepted2017-10-06en_UK
dc.date.filedepositdate2017-10-17en_UK
dc.relation.funderprojectTargeted disease prophylaxis in European fish farmingen_UK
dc.relation.funderref311993en_UK
rioxxterms.apcpaiden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionAMen_UK
local.rioxx.authorHoare, Rowena|0000-0002-9298-4275en_UK
local.rioxx.authorJung, Sung-Ju|en_UK
local.rioxx.authorNgo, Thao P H|en_UK
local.rioxx.authorBartie, Kerry|0000-0003-3037-5295en_UK
local.rioxx.authorBaily, Johanna|0000-0002-2242-7078en_UK
local.rioxx.authorThompson, Kim D|en_UK
local.rioxx.authorAdams, Alexandra|en_UK
local.rioxx.project311993|European Commission (Horizon 2020)|en_UK
local.rioxx.freetoreaddate2018-10-08en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||2018-10-07en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by-nc-nd/4.0/|2018-10-08|en_UK
local.rioxx.filenameFp_Salmon Vaccination_FSI_accep.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1050-4648en_UK
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