Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/25840
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dc.contributor.authorKeresztes, Attilaen_UK
dc.contributor.authorBender, Andrewen_UK
dc.contributor.authorBodammer, Nilsen_UK
dc.contributor.authorLindenberger, Ulmanen_UK
dc.contributor.authorShing, Yee Leeen_UK
dc.contributor.authorWerkle-Bergner, Markusen_UK
dc.date.accessioned2017-09-07T23:21:37Z-
dc.date.available2017-09-07T23:21:37Z-
dc.date.issued2017-08-22en_UK
dc.identifier.urihttp://hdl.handle.net/1893/25840-
dc.description.abstractAdaptive learning systems need to meet two complementary and partially conflicting goals: detecting regularities in the world versus remembering specific events. The hippocampus (HC) keeps a fine balance between computations that extract commonalities of incoming information (i.e., pattern completion) and computations that enable encoding of highly similar events into unique representations (i.e., pattern separation). Histological evidence from young rhesus monkeys suggests that HC development is characterized by the differential development of intrahippocampal subfields and associated networks. However, due to challenges in the in vivo investigation of such developmental organization, the ontogenetic timing of HC subfield maturation remains controversial. Delineating its course is important, as it directly influences the fine balance between pattern separation and pattern completion operations and, thus, developmental changes in learning and memory. Here, we relate in vivo, high-resolution structural magnetic resonance imaging data of HC subfields to behavioral memory performance in children aged 6–14 y and in young adults. We identify a multivariate profile of age-related differences in intrahippocampal structures and show that HC maturity as captured by this pattern is associated with age differences in the differential encoding of unique memory representations.en_UK
dc.language.isoenen_UK
dc.publisherNational Academy of Sciences of the United States of Americaen_UK
dc.relationKeresztes A, Bender A, Bodammer N, Lindenberger U, Shing YL & Werkle-Bergner M (2017) Hippocampal maturity promotes memory distinctiveness in childhood and adolescence. Proceedings of the National Academy of Sciences, 114 (34), pp. 9212-9217. https://doi.org/10.1073/pnas.1710654114en_UK
dc.rightsThis item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. Publisher policy allows this work to be made available in this repository. Published in PNAS by National Academy of Sciences of the United States of America. The original publication is available at: https://doi.org/10.1073/pnas.1710654114en_UK
dc.subjecthippocampal subfieldsen_UK
dc.subjectepisodic memoryen_UK
dc.subjectspecificityen_UK
dc.subjectpattern separationen_UK
dc.subjectchild developmenten_UK
dc.titleHippocampal maturity promotes memory distinctiveness in childhood and adolescenceen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2018-02-08en_UK
dc.rights.embargoreason[Keresztes_EtAl_V3_MainText.pdf] Publisher requires embargo of 6 months after formal publication.en_UK
dc.identifier.doi10.1073/pnas.1710654114en_UK
dc.identifier.pmid28784801en_UK
dc.citation.jtitleProceedings of the National Academy of Sciencesen_UK
dc.citation.issn1091-6490en_UK
dc.citation.volume114en_UK
dc.citation.issue34en_UK
dc.citation.spage9212en_UK
dc.citation.epage9217en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.author.emailyee.shing@stir.ac.uken_UK
dc.citation.date07/08/2017en_UK
dc.contributor.affiliationMax Planck Institute for Human Developmenten_UK
dc.contributor.affiliationMax Planck Institute for Human Developmenten_UK
dc.contributor.affiliationMax Planck Institute for Human Developmenten_UK
dc.contributor.affiliationMax Planck Institute for Human Developmenten_UK
dc.contributor.affiliationPsychologyen_UK
dc.contributor.affiliationMax Planck Institute for Human Developmenten_UK
dc.identifier.isiWOS:000408095300079en_UK
dc.identifier.scopusid2-s2.0-85027871333en_UK
dc.identifier.wtid521331en_UK
dc.contributor.orcid0000-0001-8922-7292en_UK
dc.date.accepted2017-07-10en_UK
dcterms.dateAccepted2017-07-10en_UK
dc.date.filedepositdate2017-08-24en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionAMen_UK
local.rioxx.authorKeresztes, Attila|en_UK
local.rioxx.authorBender, Andrew|en_UK
local.rioxx.authorBodammer, Nils|en_UK
local.rioxx.authorLindenberger, Ulman|en_UK
local.rioxx.authorShing, Yee Lee|0000-0001-8922-7292en_UK
local.rioxx.authorWerkle-Bergner, Markus|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2018-02-08en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||2018-02-07en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/all-rights-reserved|2018-02-08|en_UK
local.rioxx.filenameKeresztes_EtAl_V3_MainText.pdfen_UK
local.rioxx.filecount1en_UK
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