Please use this identifier to cite or link to this item:
Appears in Collections:Psychology Journal Articles
Peer Review Status: Refereed
Title: Memory integration in humans with hippocampal lesions
Author(s): Pajkert, Anna
Finke, Carsten
Shing, Yee Lee
Hoffmann, Martina
Sommer, Werner
Heekeren, Hauke R
Ploner, Christoph
Contact Email:
Keywords: decision making
memory integration
relational inference
Issue Date: Dec-2017
Citation: Pajkert A, Finke C, Shing YL, Hoffmann M, Sommer W, Heekeren HR & Ploner C (2017) Memory integration in humans with hippocampal lesions. Hippocampus, 27 (12), pp. 1230-1238.
Abstract: Adaptive behavior frequently depends on inference from past experience. Recent studies suggest that the underlying process of integrating related memories may depend on interaction between hippocampus and prefrontal cortex. Here, we investigated how hippocampal damage affects memory integration. Subjects with mediotemporal lesions and healthy controls learned a set of overlapping AB- and BC-associations (object-face- and face-object pairs) and were then tested for memory of these associations (“direct” trials) and of inferential AC-associations (“indirect” trials). The experiment consisted of four encoding/retrieval cycles. In direct trials, performance of patients and controls was similar and stable across cycles. By contrast, in indirect trials, patients and controls showed distinct patterns of behavior. Whereas patients and controls initially showed only minor differences, controls increased performance across subsequent cycles, while patient performance decreased to chance level. Further analysis suggested that this deficit was not merely a consequence of impaired associative memory but rather resulted from an additional hippocampal contribution to memory integration. Our findings further suggest that contextual factors modulate this contribution. Patient deficits in more complex memory-guided behavior may depend on the flexible interaction of hippocampus-dependent and -independent mechanisms of memory integration.
DOI Link: 10.1002/hipo.22766
Rights: This item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. This is the peer reviewed version of the following article: Pajkert A, Finke C, Shing YL, et al. Memory integration in humans with hippocampal lesions. Hippocampus. 2017;27:1230–1238, which has been published in final form at This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.

Files in This Item:
File Description SizeFormat 
Pajkert_et_al_2017.pdfFulltext - Accepted Version748.4 kBAdobe PDFView/Open

This item is protected by original copyright

Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

If you believe that any material held in STORRE infringes copyright, please contact providing details and we will remove the Work from public display in STORRE and investigate your claim.