Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/25462
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dc.contributor.authorVannuccini, Maria Luisa-
dc.contributor.authorGrassi, Giacomo-
dc.contributor.authorLeaver, Michael-
dc.contributor.authorCorsi, Ilaria-
dc.date.accessioned2017-06-07T23:06:58Z-
dc.date.issued2015-10-
dc.identifier.urihttp://hdl.handle.net/1893/25462-
dc.description.abstractThe aim of present study was to investigate the influence of titanium dioxide nanoparticles (nano-TiO 2, Aeroxide® P25) on 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) dependent biotransformation gene expression in liver of juvenile European sea bass Dicentrarchus labrax. An in vivo 7 day waterborne exposure was performed with nano-TiO2(1mg/L) and 2,3,7,8-TCDD (46pg/L), singly and in combination. The mRNA expression of aryl hydrocarbon receptor repressor (Ahrr), estrogen receptor (erβ2), ABC transport proteins as Abcb1, Abcc1-c2-g2, cytochrome P450 (cyp1a), glutathione-s-transferase (gsta), glutathione reductase (gr) and engulfment and motility (ELMO) domain-containing protein 2 (elmod2) was investigated. Ahrr,erβ2,abcc1 and abcg2 resulted down-regulated with respect to controls in all experimental groups.Co-exposure to nano-TiO2 and 2,3,7,8-TCDD caused a further significant down regulation ofahrr,erβ2,Abcb1andAbcc2compared to single chemical exposure (nano-TiO2or 2,3,7,8-TCDD alone). No effects were observed for 2,3,7,8-TCDD and nano-TiO2 alone in abcb1 gene, while abcc2 was down-regulated by nano-TiO2 alone. Cyp1a,gst and elmod2 genes were up-regulated by 2,3,7,8-TCDD and to a similar extent after co-exposure. Overall the results indicate that nano-TiO2 is unlikely to interfere with 2,3,7,8-TCDD-dependent biotransformation gene expression in the liver of European sea bass, although the effects of co-exposure observed in ABC transport mRNAs might suggest an impact on xenobiotic metabolite disposition and transport in European sea bass liver.en_UK
dc.language.isoen-
dc.publisherElsevier-
dc.relationVannuccini ML, Grassi G, Leaver M & Corsi I (2015) Combination effects of nano-TiO2 and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on biotransformation gene expression in the liver of European sea bass Dicentrarchus labrax, Comparative Biochemistry and Physiology - Part C: Toxicology and Pharmacology, 176-177, pp. 71-78.-
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.-
dc.subjectTitanium dioxideen_UK
dc.subjectBiotransformationen_UK
dc.subjectEuropean sea bassen_UK
dc.subjectGene expressionen_UK
dc.titleCombination effects of nano-TiO2 and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on biotransformation gene expression in the liver of European sea bass Dicentrarchus labraxen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-31T00:00:00Z-
dc.rights.embargoreasonThe publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.-
dc.identifier.doihttp://dx.doi.org/10.1016/j.cbpc.2015.07.009-
dc.identifier.pmid26235595-
dc.citation.jtitleComparative Biochemistry and Physiology - Part C: Toxicology and Pharmacology-
dc.citation.issn1532-0456-
dc.citation.volume176-177-
dc.citation.spage71-
dc.citation.epage78-
dc.citation.publicationstatusPublished-
dc.citation.peerreviewedRefereed-
dc.type.statusPublisher version (final published refereed version)-
dc.author.emailmjl1@stir.ac.uk-
dc.citation.date30/07/2015-
dc.contributor.affiliationUniversity of Siena-
dc.contributor.affiliationUniversity of Siena-
dc.contributor.affiliationAquaculture-
dc.contributor.affiliationUniversity of Siena-
dc.rights.embargoterms2999-12-31-
dc.rights.embargoliftdate2999-12-31-
dc.identifier.isi000361577400008-
Appears in Collections:Aquaculture Journal Articles

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