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dc.contributor.authorJackson, Philippa A-
dc.contributor.authorForster, Joanne S-
dc.contributor.authorBell, J Gordon-
dc.contributor.authorDick, James R-
dc.contributor.authorYounger, Irene-
dc.contributor.authorKennedy, David O-
dc.description.abstractA number of recent trials have demonstrated positive effects of dietary supplementation with the omega-3 polyunsaturated fatty acids ( n-3 PUFAs), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on measures of cognitive function in healthy young and older adults. One potential mechanism by which EPA, and DHA in particular, may exert these effects is via modulation of cerebral hemodynamics. In order to investigate the effects of DHA alone or provided as one component of a multinutrient supplement (also including Gingko biloba, phosphatidylserine and vitamins B9 and B12) on measures of cerebral hemodynamics and cognitive function, 86 healthy older adults aged 50–70 years who reported subjective memory deficits were recruited to take part in a six month daily dietary supplementation trial. Relative changes in the concentration of oxygenated hemoglobin and deoxygenated hemoglobin were assessed using Near Infrared Spectroscopy (NIRS) during the performance of cognitive tasks prior to and following the intervention period. Performance on the cognitive tasks was also assessed. No effect of either active treatment was found for any of the NIRS measures or on the cognitive performance tasks, although the study was limited by a number of factors. Further work should continue to evaluate more holistic approaches to cognitive aging.en_UK
dc.relationJackson PA, Forster JS, Bell JG, Dick JR, Younger I & Kennedy DO (2016) DHA Supplementation Alone or in Combination with Other Nutrients Does not Modulate Cerebral Hemodynamics or Cognitive Function in Healthy Older Adults, Nutrients, 8 (2), Art. No.: 86.-
dc.rights© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (
dc.subjectomega-3 polyunsaturated fatty acidsen_UK
dc.subjectcerebral blood flowen_UK
dc.subjectcognitive declineen_UK
dc.titleDHA Supplementation Alone or in Combination with Other Nutrients Does not Modulate Cerebral Hemodynamics or Cognitive Function in Healthy Older Adultsen_UK
dc.typeJournal Articleen_UK
dc.type.statusPublisher version (final published refereed version)-
dc.contributor.affiliationNorthumbria University-
dc.contributor.affiliationNorthumbria University-
dc.contributor.affiliationNorthumbria University-
Appears in Collections:Aquaculture Journal Articles

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