Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/25281
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dc.contributor.authorJin, Minen_UK
dc.contributor.authorMonroig, Oscaren_UK
dc.contributor.authorLu, Youen_UK
dc.contributor.authorYuan, Yeen_UK
dc.contributor.authorDing, Liyunen_UK
dc.contributor.authorTocher, Douglas Ren_UK
dc.contributor.authorZhou, Qicunen_UK
dc.date.accessioned2017-05-24T22:52:28Z-
dc.date.available2017-05-24T22:52:28Z-
dc.date.issued2017-04-21en_UK
dc.identifier.othere0176216en_UK
dc.identifier.urihttp://hdl.handle.net/1893/25281-
dc.description.abstractAn 8-week feeding trial was conducted to investigate the effects of dietary docosahexaenoic to eicosapentaenoic acid ratio (DHA/EPA) on growth performance, fatty acid profiles, anti- oxidant capacity, hematological characteristics and expression of some lipid metabolism related genes of juvenile black seabream (Acanthopagrus schlegelii) of initial weight 9.47 ± 0.03 g. Five isonitrogenous and isolipidic diets (45% crude protein and 14% crude lipid) were formulated to contain graded DHA/EPA ratios of 0.65, 1.16, 1.60, 2.03 and 2.67. There were no differences in growth performance and feed utilization among treatments. Fish fed higher DHA/EPA ratios had higher malondialdehyde (MDA) contents in serum than lower ratios. Serum triacylglycerol (TAG) content was significantly higher in fish fed the lowest DHA/EPA ratio. Tissue fatty acid profiles reflected the diets despite down-regulation of LC- PUFA biosynthesis genes, fatty acyl desaturase 2 (fads2) and elongase of very long-chain fatty acids 5 (elovl5), by high DHA/EPA ratios. Expression of acetyl-CoA carboxylase alpha (accα) and carnitine palmitoyl transferase 1A (cpt1a) were up-regulated by high DHA/EPA ratio, whereas sterol regulatory element-binding protein-1 (srebp-1) and hormone-sensitive lipase (hsl) were down-regulated. Fatty acid synthase (fas), 6-phosphogluconate dehydro- genase (6pgd) and peroxisome proliferator-activated receptor alpha (pparα) showed highest expression in fish fed intermediate (1.16) DHA/EPA ratio. Overall, this study indicated that dietary DHA/EPA ratio affected fatty acid profiles and significantly influenced lipid metabo- lism including LC-PUFA biosynthesis and other anabolic and catabolic pathways, and also had impacts on antioxidant capacity and hematological characteristics.en_UK
dc.language.isoenen_UK
dc.publisherPublic Library of Scienceen_UK
dc.relationJin M, Monroig O, Lu Y, Yuan Y, Ding L, Tocher DR & Zhou Q (2017) Dietary DHA/EPA ratio affected tissue fatty acid profiles, antioxidant capacity, hematological characteristics and expression of lipid-related genes but not growth in juvenile black seabream (Acanthopagrus schlegelii). PLoS ONE, 12 (4), Art. No.: e0176216. https://doi.org/10.1371/journal.pone.0176216en_UK
dc.rights© 2017 Jin et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.titleDietary DHA/EPA ratio affected tissue fatty acid profiles, antioxidant capacity, hematological characteristics and expression of lipid-related genes but not growth in juvenile black seabream (Acanthopagrus schlegelii)en_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1371/journal.pone.0176216en_UK
dc.identifier.pmid28430821en_UK
dc.citation.jtitlePLoS ONEen_UK
dc.citation.issn1932-6203en_UK
dc.citation.volume12en_UK
dc.citation.issue4en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.citation.date21/04/2017en_UK
dc.contributor.affiliationNingbo Universityen_UK
dc.contributor.affiliationComplex Systems - LEGACYen_UK
dc.contributor.affiliationNingbo Universityen_UK
dc.contributor.affiliationNingbo Universityen_UK
dc.contributor.affiliationNingbo Universityen_UK
dc.contributor.affiliationInstitute of Aquacultureen_UK
dc.contributor.affiliationNingbo Universityen_UK
dc.identifier.isiWOS:000399876100034en_UK
dc.identifier.scopusid2-s2.0-85018164489en_UK
dc.identifier.wtid531038en_UK
dc.contributor.orcid0000-0001-8712-0440en_UK
dc.contributor.orcid0000-0002-8603-9410en_UK
dc.date.accepted2017-03-21en_UK
dcterms.dateAccepted2017-03-21en_UK
dc.date.filedepositdate2017-04-22en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorJin, Min|en_UK
local.rioxx.authorMonroig, Oscar|0000-0001-8712-0440en_UK
local.rioxx.authorLu, You|en_UK
local.rioxx.authorYuan, Ye|en_UK
local.rioxx.authorDing, Liyun|en_UK
local.rioxx.authorTocher, Douglas R|0000-0002-8603-9410en_UK
local.rioxx.authorZhou, Qicun|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2017-04-24en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by/4.0/|2017-04-24|en_UK
local.rioxx.filenameJin PLoS ONE 2017 (black seabream).pdfen_UK
local.rioxx.filecount1en_UK
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