Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/25204
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dc.contributor.authorMcCallum, Hamishen_UK
dc.contributor.authorFenton, Andrewen_UK
dc.contributor.authorHudson, Peter Jen_UK
dc.contributor.authorLee, Brianen_UK
dc.contributor.authorLevick, Bethen_UK
dc.contributor.authorNorman, Rachelen_UK
dc.contributor.authorPerkins, Sarahen_UK
dc.contributor.authorViney, Marken_UK
dc.contributor.authorWilson, Anthonyen_UK
dc.contributor.authorLello, Joanneen_UK
dc.date.accessioned2017-04-21T00:13:37Z-
dc.date.available2017-04-21T00:13:37Z-
dc.date.issued2017-05-05en_UK
dc.identifier.other20160084en_UK
dc.identifier.urihttp://hdl.handle.net/1893/25204-
dc.description.abstractTransmission is a fundamental step in the life cycle of every parasite but it is also one of the most challenging processes to model and quantify. In most host–parasite models, the transmission process is encapsulated by a single parameterβ. Many different biological processes and interactions, acting on both hosts and infectious organisms, are subsumed in this single term. There are, however, at least two undesirable consequences of this high level of abstraction. First, nonlinearities and heterogeneities that can be critical to the dynamic behaviour of infections are poorly represented; second, estimating the transmission coefficientβfrom field data is often very difficult. In this paper, we present a conceptual model, which breaks the transmission process into its component parts. This deconstruction enables us to identify circumstances that generate nonlinearities in transmission, with potential implications for emergent transmission behaviour at individual and population scales. Such behaviour cannot be explained by the traditional linear transmission frameworks. The deconstruction also provides a clearer link to the empirical estimation of key components of transmission and enables the construction of flexible models that produce a unified understanding of the spread of both micro- and macro-parasite infectious disease agents.en_UK
dc.language.isoenen_UK
dc.publisherThe Royal Societyen_UK
dc.relationMcCallum H, Fenton A, Hudson PJ, Lee B, Levick B, Norman R, Perkins S, Viney M, Wilson A & Lello J (2017) Breaking beta: deconstructing the parasite transmission function. Philosophical Transactions B: Biological Sciences, 372 (1719), Art. No.: 20160084. https://doi.org/10.1098/rstb.2016.0084en_UK
dc.rights© 2017 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.subjectcomputational biologyen_UK
dc.subjectecologyen_UK
dc.subjectevolutionen_UK
dc.subjecthealth and disease and epidemiologyen_UK
dc.subjecttheoretical biologyen_UK
dc.titleBreaking beta: deconstructing the parasite transmission functionen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1098/rstb.2016.0084en_UK
dc.identifier.pmid28289252en_UK
dc.citation.jtitlePhilosophical Transactions of the Royal Society B: Biological Sciencesen_UK
dc.citation.issn1471-2970en_UK
dc.citation.issn0962-8436en_UK
dc.citation.volume372en_UK
dc.citation.issue1719en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailr.a.norman@stir.ac.uken_UK
dc.citation.date05/03/2017en_UK
dc.contributor.affiliationGriffith Universityen_UK
dc.contributor.affiliationUniversity of Liverpoolen_UK
dc.contributor.affiliationPenn State Universityen_UK
dc.contributor.affiliationUniversity of Stirlingen_UK
dc.contributor.affiliationUniversity of Liverpoolen_UK
dc.contributor.affiliationComplex Systems - LEGACYen_UK
dc.contributor.affiliationCardiff Universityen_UK
dc.contributor.affiliationUniversity of Bristolen_UK
dc.contributor.affiliationPirbright Insituteen_UK
dc.contributor.affiliationCardiff Universityen_UK
dc.identifier.isiWOS:000397800300003en_UK
dc.identifier.scopusid2-s2.0-85015159197en_UK
dc.identifier.wtid533374en_UK
dc.contributor.orcid0000-0002-7398-6064en_UK
dc.date.accepted2016-12-22en_UK
dcterms.dateAccepted2016-12-22en_UK
dc.date.filedepositdate2017-03-27en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorMcCallum, Hamish|en_UK
local.rioxx.authorFenton, Andrew|en_UK
local.rioxx.authorHudson, Peter J|en_UK
local.rioxx.authorLee, Brian|en_UK
local.rioxx.authorLevick, Beth|en_UK
local.rioxx.authorNorman, Rachel|0000-0002-7398-6064en_UK
local.rioxx.authorPerkins, Sarah|en_UK
local.rioxx.authorViney, Mark|en_UK
local.rioxx.authorWilson, Anthony|en_UK
local.rioxx.authorLello, Joanne|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2017-03-27en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by/4.0/|2017-03-27|en_UK
local.rioxx.filenamebreaking beta.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source0962-8436en_UK
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